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Complement plays a major role in inflammatory diseases, but its involvement and mechanisms of activation in patients with nasal polyps are not known. After earlier studies discovering

autoantibodies in patients with nasal polyps, recent study sought to investigate the nature, extent, and location of complement activation in nasal tissue of patients with nasal polyps.

Specifically, we were interested in whether antibody-mediated activation through the classical pathway was a major mechanism for complement activation in patients with nasal polyps. Nasal

tissue was obtained from patients with nasal polyps and control subjects. Tissue homogenates were analyzed for complement activation products (ELISA-C5b-9, C4d, activated C1, and C5a) and

major complement-fixing antibodies (Luminex). Tissue sections were stained for C5b-9, C4d, and laminin. Antibodies were purified with protein A/G columns from nasal polyps (NP), matching

patient serum, and control serum and assayed for basement membrane binding by means of ELISA. C5b-9 levels were significantly increased in NP tissue compared with uncinate tissue (UT) of

patients with nasal polyps. Nasal polyps tissue extracts had significantly more anti-basement membrane antibodies than sera from patients with Nasal Polyps and control subjects (P <

.0001). Levels of C5b-9, C4d, and activated C1 were significantly increased locally in NP tissue. C5b-9 and C4d were almost universally deposited linearly along the basement membrane of NP

tissue. Furthermore, activated C1 levels were best correlated with local immunoglobulin and C5a levels. Together, these data suggest that the classical pathway plays a major role in

complement activation in patients with Nasal polyps. Natural treatment will be the next step to cure nasal polyps. Next : BEST WAY TO TREAT NASAL POLYPS NATURALLY AT HOME _Originally

published at __https://fastway4you.com__ on September 21, 2020._