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ABSTRACT BACKGROUND: The gastric hormone ghrelin appears a useful agent to stimulate food intake in people with anorexia of illness. The loss of ghrelin's acyl group renders it

inactive, thus it has been thought that subcutaneous administration may be problematic. OBJECTIVE: To investigate whether human subjects are sensitive to the effects of ghrelin administered

by single subcutaneous injection. STUDY DESIGN: Randomized, double-blind, placebo-controlled trial. SUBJECTS: Sixteen healthy lean volunteers (eight men and eight women). PROTOCOL: Fasted

subjects received subcutaneous injections of ghrelin (3.6 nmol/kg) or saline. After 30 min, a buffet breakfast was served. RESULTS: Ghrelin injection increased energy intake by 27% (ghrelin

5076±691 kJ versus saline 4230±607 kJ, _P_=0.04). Ghrelin appeared to enhance the perceived palatability of the food offered (palatability score: ghrelin 81.1±3.6 versus saline 70.0±4.4;

_P_=0.03). CONCLUSIONS: These results suggest that subcutaneous ghrelin is effective at stimulating energy intake and improving palatability and may be of direct use in the treatment of

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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS FASTING APPETITE-RELATED GUT HORMONE RESPONSES AFTER WEIGHT LOSS INDUCED BY CALORIE RESTRICTION, EXERCISE, OR BOTH IN PEOPLE

WITH OVERWEIGHT OR OBESITY: A META‐ANALYSIS Article Open access 10 February 2025 PLASMA CONCENTRATION OF GASTROINTESTINAL HORMONES AND SUBJECTIVE APPETITE RATINGS AFTER DIET OR BARIATRIC

SURGERY: 1-YEAR RESULTS FROM THE DISGAP STUDY Article 21 November 2024 INVESTIGATING RELATIONSHIPS BETWEEN POST-PRANDIAL GUT HORMONE RESPONSES AND TASTE LIKING RATINGS PRIOR TO AND FOLLOWING

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ACKNOWLEDGEMENTS We thank Professor Malcolm Allison, Dr Mandy Donaldson, the Sir John McMichael Centre and the volunteers who participated in the study. We also thank the MRC and Wellcome

Trust for support. MD and NN are funded by Wellcome Trust Clinical Research Training Fellowships, MP is funded by BBSRC and MM by a Gulbenkian Foundation Grant. AUTHOR INFORMATION Author

notes * M R Druce and N M Neary: These authors contributed equally to this work. AUTHORS AND AFFILIATIONS * Department of Metabolic Medicine, Imperial College, Hammersmith Hospital Campus,

London, UK M R Druce, N M Neary, C J Small, J Milton, M Monteiro, M Patterson, M A Ghatei & S R Bloom Authors * M R Druce View author publications You can also search for this author

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Bloom. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Druce, M., Neary, N., Small, C. _et al._ Subcutaneous administration of ghrelin stimulates energy

intake in healthy lean human volunteers. _Int J Obes_ 30, 293–296 (2006). https://doi.org/10.1038/sj.ijo.0803158 Download citation * Received: 07 January 2005 * Revised: 30 August 2005 *

Accepted: 21 September 2005 * Published: 25 October 2005 * Issue Date: 01 February 2006 * DOI: https://doi.org/10.1038/sj.ijo.0803158 SHARE THIS ARTICLE Anyone you share the following link

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content-sharing initiative KEYWORDS * appetite * ghrelin * food intake * growth hormone secretagogues