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ABSTRACT Cyclins are major cell cycle regulators which role in malignant transformation remains controversial. In this report we describe a new mechanism of cyclin oncogenic activation. We

demonstrate that an altered form of cyclin A2 (S2A) which N-terminal part is replaced by the hepatitis B virus envelope protein transforms normal rat kidney cells and cooperates with _RAS_

to transform rat embryo fibroblasts. In contrast, neither the viral moiety, nor a full length or N-terminally deleted cyclin A2 show these oncogenic properties. S2A oncogenicity arises from

its binding to cyclin dependent kinases, since mutation in the MRAIL sequence abolishes transformation and correlates with an abnormal cellular localization in the endoplasmic reticulum

membrane. Together, these results implicate modification in the cellular distribution of a cell cycle regulator as a mechanism of virally-induced transformation. Access through your

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FORMATION DRIVES GENOMIC INSTABILITY Article Open access 26 November 2024 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * INSERM U370 and Liver Unit, Necker Institute and Hospital, Paris,

75015, France Carmen Berasain, Deva Patil, Shih-Min Huang, Hélène Mouly & Christian Bréchot * Department of Biology, San Francisco State University, San Francisco, California, USA Eve

Perara Authors * Carmen Berasain View author publications You can also search for this author inPubMed Google Scholar * Deva Patil View author publications You can also search for this

author inPubMed Google Scholar * Eve Perara View author publications You can also search for this author inPubMed Google Scholar * Shih-Min Huang View author publications You can also search

for this author inPubMed Google Scholar * Hélène Mouly View author publications You can also search for this author inPubMed Google Scholar * Christian Bréchot View author publications You

can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Berasain, C., Patil, D., Perara, E. _et al._

Oncogenic activation of a human cyclin A2 targeted to the endoplasmic reticulum upon Hepatitis B virus genome insertion. _Oncogene_ 16, 1277–1288 (1998).

https://doi.org/10.1038/sj.onc.1201893 Download citation * Received: 18 November 1997 * Revised: 02 February 1998 * Accepted: 05 February 1998 * Published: 19 March 1998 * Issue Date: 12

March 1998 * DOI: https://doi.org/10.1038/sj.onc.1201893 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * cyclin A * hepatitis B virus *

hepatocellular carcinoma * oncogenic transformation