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ABSTRACT Mutational activation of Ras promotes oncogenesis by disrupting a multitude of normal cellular processes. Perhaps, best characterized and understood are the mechanisms by which

oncogenic Ras promotes deregulated cell cycle progression and uncontrolled cellular proliferation. However, it is now clear that oncogenic Ras can also deregulate processes that control

apoptosis. In light of the diversity of downstream effector targets known to facilitate Ras function, it is perhaps not surprising that Ras regulation of cell survival is complex, involving

the balance and interplay of multiple signaling networks. While our understanding of these events is still far from complete, and is complicated by cell type and signaling context

differences, several important mechanisms have begun to emerge. We review the role and mechanism of specific effectors in regulating the antiapoptotic (Raf, phosphatidylinositol 3-kinase and

Tiam1) and apoptotic (Nore1 and RASSF1) actions of oncogenic Ras, and discuss the possibility that the effector actions of p120RasGAP make a significant contribution to Ras regulation of

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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS ONCOGENIC KRAS IS DEPENDENT UPON AN EFR3A-PI4KA SIGNALING AXIS FOR POTENT TUMORIGENIC ACTIVITY Article Open access 09

September 2021 ZNF768 LINKS ONCOGENIC RAS TO CELLULAR SENESCENCE Article Open access 17 August 2021 CHARACTERIZATION OF MUTANT VERSIONS OF THE R-RAS2/TC21 GTPASE FOUND IN TUMORS Article Open

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Zimmermann S and Moelling K . (1999). _Science_, 286, 1741–1744. Download references ACKNOWLEDGEMENTS We apologize for not being able to cite original work of many colleagues due to space

constraints. Our studies were supported by grants from the National Institutes of Health (CA42978, CA69577 and CA67771), and from the Lustgarten Foundation for Pancreatic Cancer Research

(LF-056). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, 27599,

NC, USA Adrienne D Cox & Channing J Der * Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, 27599, NC,

USA Adrienne D Cox Authors * Adrienne D Cox View author publications You can also search for this author inPubMed Google Scholar * Channing J Der View author publications You can also search

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Der, C. The dark side of Ras: regulation of apoptosis. _Oncogene_ 22, 8999–9006 (2003). https://doi.org/10.1038/sj.onc.1207111 Download citation * Published: 08 December 2003 * Issue Date:

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transduction * small GTPase