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ABSTRACT MAST cells are generally thought to be derived from undifferentiated mesenchymal cells and perhaps heteroplastically from lymphocytes, plasma cells or histiocytes1. Various

conditions can cause mast cell granules to be discharged in a manner that has led some investigators to believe the cell is destroyed in the process. Yet Padawer2 reported never having seen

a mast cell in mitosis during his extensive investigation of these cells with colchicine and related substances. This does not preclude the possibility of mast cells being continually

replaced by transformations from a population of proliferating precursor cells. Extensive mast cell degranulation occurs after administration of compound 48/80 and is followed within 4 days

by the re-appearance of granulated mast cells3. This sequence of events was investigated radioautographically with sulphur-35 by Watson and Kennedy4. They observed sulphur-35 uptake within

24 hr. by ‘ghost cells’ which had a tissue distribution equivalent to that of the original granulated mast cells. Access through your institution Buy or subscribe This is a preview of

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ORIGINS AND HETEROGENEITY OF MAST CELLS Article 24 May 2022 THE UNIVERSAL STEM CELL Article Open access 28 October 2022 SIMULTANEOUS REDUCTION OF ALL ORMDL PROTEINS DECREASES THE THRESHOLD

OF MAST CELL ACTIVATION Article Open access 14 June 2023 REFERENCES * Kelsall, M. A., and Crabb, E. D., _Lymphocytes and Mast Cells_ (Williams and Wilkins, Baltimore, 1959). Google Scholar 

* Padawer, J., _J. Nat. Cancer Inst._, 25, 731 (1960). Article  CAS  Google Scholar  * Riley, J. F., _The Mast Cells_ (Livingstone, London, 1959). Google Scholar  * Watson, W. C., and

Kennedy, J. S., _Brit. J. Exp. Path._, 41, 385 (1960). CAS  PubMed  Google Scholar  * Walker, B. E., _Tex. Rept. Biol. Med._, 17, 375 (1959). Google Scholar  * Pearse, A. G. E.,

_Histochemistry_ (Little and Brown, Boston, 1960). Google Scholar  * Messier, B., and Leblond, C. P., _Amer. J. Anat._, 106, 247 (1960). Article  CAS  Google Scholar  * Walker, B. E., _Amer.

J. Anat._, 107, 95 (1960). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Anatomy, University of Texas Medical Branch,

Galveston, Texas BRUCE E. WALKER Authors * BRUCE E. WALKER View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE WALKER, B. Mast Cell Turn-over in Adult Mice. _Nature_ 192, 980–981 (1961). https://doi.org/10.1038/192980a0 Download citation * Issue Date:

09 December 1961 * DOI: https://doi.org/10.1038/192980a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

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