Reader TTS

ABSTRACT IT has been reported from this laboratory that the extreme susceptibility of adrenalectomized dogs to endotoxin is mainly a result of the development of an endogenous factor which

produces marked hepatic engorgement of the shocked animals1,2. This factor seemed to be formed in the liver when its glycogen becomes depleted in the absence of glucocorticoids. The

appearance of this factor in the circulating blood could be detected by injecting the shock serum into a normal recipient dog under pentobarbitone sodium anaesthesia when a delayed depressor

response caused by induction of hepatic engorgement could be observed. This “shock-factor” in the serum was found to be non-dialysable, heat-unstable (inactivated by heating at 56° C for 30

min) and contained in the serum protein fraction precipitable by 20 per cent to 34 per cent saturation with ammonium sulphate. Further experiments, shortly to be published, showed that

there was no appreciable release of histamine from the liver of endotoxin-shocked adrenalectomized dogs and that the “shock-factor” does not act as a histamine-releaser. The “shock-factor”

and the hepatic engorgement were examined, therefore, in relation to an induction of histamine formation in the liver. Dogs are known to have no detectable histamine forming capacity in

their tissues3, and so the possibility that histamine forming activity was induced in the liver of endotoxin-shocked adrenalectomized dogs was therefore examined, using the method of Waton3

to determine this capacity. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access

to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our

FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS ANGIOTENSIN-(1–7) TREATMENT BLOCKS LIPOPOLYSACCHARIDE-INDUCED ORGAN DAMAGE, PLATELET DYSFUNCTION, AND IL-6 AND NITRIC

OXIDE PRODUCTION IN RATS Article Open access 12 January 2021 FIBRINOLYTIC SYSTEM ACTIVATION IMMEDIATELY FOLLOWING TRAUMA WAS QUICKLY AND INTENSELY SUPPRESSED IN A RAT MODEL OF SEVERE BLUNT

TRAUMA Article Open access 13 October 2021 SYMPATHETIC NERVES CONTROL BACTERIAL CLEARANCE Article Open access 14 September 2020 REFERENCES * Fukuda, T., Kobayashi, T., and Okada, M.,

_Nature_, 204, 585 (1964). Article  ADS  CAS  Google Scholar  * Fukuda, T., Okada, M., and Kobayashi, T., _Jap. J. Physiol._, 14, 560 (1964). Article  CAS  Google Scholar  * Waton, N. G.,

_Brit. J. Pharmacol._, 11, 119 (1956). CAS  PubMed  Google Scholar  * Weissbach, H., Lovenberg, W., and Udenfriend, S., _Biochim. Biophys. Acta_, 50, 177 (1961). Article  CAS  Google Scholar

  * Weil, M. H., and Spink, W. W., _J. Lab. Clin. Med._, 50, 501 (1957). CAS  PubMed  Google Scholar  * Hinshaw, L. B., Vick, J. A., Carlson, C. H., and Fan, Y. L., _Proc. Soc. Exp. Biol._,

104, 379 (1960). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Physiology, Chiba University School of Medicine, Japan TOKURO

FUKUDA Authors * TOKURO FUKUDA View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE FUKUDA, T. Induction of Histamine Forming Capacity in Canine Liver by Endotoxin. _Nature_ 214, 107–108 (1967). https://doi.org/10.1038/214107a0 Download citation * Issue Date:

01 April 1967 * DOI: https://doi.org/10.1038/214107a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative