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Access through your institution Buy or subscribe T cell large granular lymphocytic (LGL) leukemia is usually an indolent lymphoproliferative disorder which results from clonal expansion of

previously activated cytotoxic T cells.1,2 The cells of most T-LGL leukemias express characteristic T cell differentiation antigens (ie CD3, CD8) and bear rearranged T cell receptor (TCR)

beta, gamma and delta chain genes.1 In addition, T-LGLs usually express the human natural killer (NK) marker (CD57); however, they display poor NK activity. The association of clonal T-large

granular lymphocyte proliferations (CT-LGLP) with clonal B cell lymphoproliferative disorders (CB-LPD), although rare, is now well recognized.1,3,4 We present eight patients with

simultaneous occurrence of CTLGLP with CBLPD and discuss possible pathogenetic mechanisms underlying such associations. Case histories were as follows (see also Tables 1 and 2 for

clinicolaboratory and molecular (PCR) results; immunophenotypic results refer to percentages of positive cells). This is a preview of subscription content, access via your institution ACCESS

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institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Lamy T, Loughran TP . Current concepts: large granular lymphocyte leukemia _Blood Rev_ 1999 13: 236–240

Article  Google Scholar  * Dhodapkar M, Li C, Lust J, Tefferi A, Phyliky R . Clinical spectrum of clonal proliferations of T-large granular lymphocytes: a T-cell clonopathy of undetermined

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granular lymphocytes and natural killer cells _Blood_ 1994 83: 301–303 CAS  PubMed  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Hemopathology Unit,

Evangelismos Hospital, Athens, Greece T Papadaki * First Department of Medicine, University of Athens, Athens, Greece K Stamatopoulos & C Kosmas * Immunology Laboratory, G Gennimatas

Hospital, Athens, Greece G Paterakis * Immunology Laboratory, Evangelismos Hospital, Athens, Greece V Kapsimali * Hematology Unit, Sismanogleion General Hospital, Athens, Greece G Kokkini *

Second Propaedeutic Department of Medicine, University of Athens, Athens, Greece Th Economopoulos * Hematology Department, Amalia Fleming Hospital, Athens, Greece K Stefanoudaki-Sofianatou *

Hematology Department, G Gennimatas Hospital, Athens, Greece T Marinakis * Elpis, Municipal Hospital of Athens, Athens, Greece E Gardikas * Second Department of Medicine, University of

Athens, Athens, Greece T Kalmantis Authors * T Papadaki View author publications You can also search for this author inPubMed Google Scholar * K Stamatopoulos View author publications You

can also search for this author inPubMed Google Scholar * C Kosmas View author publications You can also search for this author inPubMed Google Scholar * G Paterakis View author publications

You can also search for this author inPubMed Google Scholar * V Kapsimali View author publications You can also search for this author inPubMed Google Scholar * G Kokkini View author

publications You can also search for this author inPubMed Google Scholar * Th Economopoulos View author publications You can also search for this author inPubMed Google Scholar * K

Stefanoudaki-Sofianatou View author publications You can also search for this author inPubMed Google Scholar * T Marinakis View author publications You can also search for this author

inPubMed Google Scholar * E Gardikas View author publications You can also search for this author inPubMed Google Scholar * T Kalmantis View author publications You can also search for this

author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Papadaki, T., Stamatopoulos, K., Kosmas, C. _et al._ Clonal T-large

granular lymphocyte proliferations associated with clonal B cell lymphoproliferative disorders: report of eight cases. _Leukemia_ 16, 2167–2169 (2002). https://doi.org/10.1038/sj.leu.2402643

Download citation * Received: 09 February 2002 * Accepted: 14 May 2002 * Published: 02 October 2002 * Issue Date: 01 October 2002 * DOI: https://doi.org/10.1038/sj.leu.2402643 SHARE THIS

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