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ABSTRACT We have previously shown that ICAM-1-deficient mice were resistant to lymphoma dissemination of intravenously injected 164T2 lymphoma cells. Highly aggressive variants of this cell

line, however, could overcome this resistance. To discern the complex pattern of gene expression involved in the evolution of aggressiveness in lymphoma cells, we compared the transcriptome

of 164T2 cells with that of their aggressive variants using cDNA arrays. We identified several genes that were differentially expressed in nonmetastatic lymphoma cells and their metastatic

variants. Galectin-7, associated with the development of chemically induced mammary carcinoma, was one such gene whose expression was significantly upregulated. We showed that it was

constitutively expressed in aggressive variants, at both mRNA and protein levels. Galectin-7 expression in aggressive lymphoma cells was induced upon _in vivo_ selection in several organs,

including the thymus, the spleen and kidneys. We also showed that treatment of nonaggressive lymphoma cells with 5-aza-2′-deoxycytidine was sufficient to induce galectin-7 gene expression.

This report is the first to show that galectin-7 is expressed in aggressive lymphoma. Access through your institution Buy or subscribe This is a preview of subscription content, access via

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS TRANSCRIPTOMIC CLASSIFICATION OF DIFFUSE LARGE B-CELL LYMPHOMA

IDENTIFIES A HIGH-RISK ACTIVATED B-CELL-LIKE SUBPOPULATION WITH TARGETABLE MYC DYSREGULATION Article Open access 08 August 2024 DISSECTING INTRATUMOUR HETEROGENEITY OF NODAL B-CELL LYMPHOMAS

AT THE TRANSCRIPTIONAL, GENETIC AND DRUG-RESPONSE LEVELS Article 15 June 2020 MUSASHI 2 INFLUENCES CHRONIC LYMPHOCYTIC LEUKEMIA CELL SURVIVAL AND GROWTH MAKING IT A POTENTIAL THERAPEUTIC

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ACKNOWLEDGEMENTS This work was supported by a grant from the Canadian Institute for Health Research (YSP and EFP). YSP is a scholar of the Fonds de la Recherche en Santé du Québec (FRSQ). MD

and JM are supported by studentships from La Fondation Armand-Frappier and the Fond pour la Formation de Chercheur et Aide à la Recherche (FCAR), respectively. We thank Ms Doris Legault and

Claire Beauchemin for their excellent technical assistance. We fondly dedicate this paper to Claire Beauchemin, a key member of our research group for 25 years, who died on 14 May 2002.

AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * INRS-Institut Armand-Frappier, University of Québec, Laval, Québec, Canada S Moisan, M Demers, J Mercier, E F Potworowski & Y St-Pierre *

CNRS, UPR2169, Instabilité Génétique et Cancer, 7,, Villejuif, 94801, France T Magnaldo Authors * S Moisan View author publications You can also search for this author inPubMed Google

Scholar * M Demers View author publications You can also search for this author inPubMed Google Scholar * J Mercier View author publications You can also search for this author inPubMed 

Google Scholar * T Magnaldo View author publications You can also search for this author inPubMed Google Scholar * E F Potworowski View author publications You can also search for this

author inPubMed Google Scholar * Y St-Pierre View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Moisan, S., Demers, M., Mercier, J. _et al._ Upregulation of galectin-7 in murine lymphoma cells is associated with progression toward an aggressive phenotype.

_Leukemia_ 17, 751–759 (2003). https://doi.org/10.1038/sj.leu.2402870 Download citation * Received: 15 April 2002 * Accepted: 26 November 2002 * Published: 08 April 2003 * Issue Date: 01

April 2003 * DOI: https://doi.org/10.1038/sj.leu.2402870 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * cDNA array * galectin-7 * lymphoma * DNA

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