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ABSTRACT LEVAMISOLE (2,3,5,6-tetrahydro-6-phenylimidazo (2, 1-b) thiazole) a compound known to be active against a wide range of nematodes1,2, has been reported to enhance the humoral and

cellular immune responses of animals and to reduce the incidence of both primary tumours and lung metastases in the Lewis lung (3a) tumour system in C57BL mice3. We report here studies on

the effect of levamisole on the growth of four transplantable tumours, all known to be immunogenic. They were: a transplantable adenovirus 12-induced tumour of CBA mice4; a chick embryo

lethal orphan (CELO) virus-induced tumour of hamsters5; a Moloney leukaemia virus-induced lymphoma of BALB/c mice6; and a chemically-induced metastasising anaplastic neoplasm of inbred

rats7. We also studied the effect of levamisole on the humoral antibody response to influenza virus vaccine in hamsters. Access through your institution Buy or subscribe This is a preview of

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2024 EVALUATION OF THE ANTI-INFLAMMATORY, ANALGESIC, ANTI-PYRETIC AND ANTI-ULCEROGENIC POTENTIALS OF SYNTHETIC INDOLE DERIVATIVES Article Open access 27 May 2023 REFERENCES * Corba, J.,

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  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Pathology, University of Sheffield Medical School, Beech Hill Road, Sheffield, UK C. W. POTTER, I. CARR, R.

JENNINGS, R. C. REES, F. MCGINTY & V. M. RICHARDSON Authors * C. W. POTTER View author publications You can also search for this author inPubMed Google Scholar * I. CARR View author

publications You can also search for this author inPubMed Google Scholar * R. JENNINGS View author publications You can also search for this author inPubMed Google Scholar * R. C. REES View

author publications You can also search for this author inPubMed Google Scholar * F. MCGINTY View author publications You can also search for this author inPubMed Google Scholar * V. M.

RICHARDSON View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE POTTER,

C., CARR, I., JENNINGS, R. _et al._ Levamisole inactive in treatment of four animal tumours. _Nature_ 249, 567–569 (1974). https://doi.org/10.1038/249567a0 Download citation * Received: 05

February 1974 * Revised: 20 May 1974 * Issue Date: 07 June 1974 * DOI: https://doi.org/10.1038/249567a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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