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ABSTRACT THE cell surface may be involved in the metastatic process of cancer cells1. To determine whether membrane properties influence or reflect the metastasising capacity, it is

essential to have metastasising and non-metastasising variants of the same tumour. Lectins which bind specifically to surface carbohydrates2 have been used successfully as selective agents

to obtain cells with membrane carbohydrate alterations3–5. We have selected variants of melanoma cells for surface differences in using toxic concentrations of lectins in the hope that such

variants would exhibit different metastasising capacities. We report here the isolation of variants from metastasising melanoma cells resistant to toxic concentrations of wheat germ

agglutinin (WGA). These variants show reduced to a loss of metastasising capacity and altered surface properties. Access through your institution Buy or subscribe This is a preview of

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MICE IDENTIFIES NOVEL MEMBRANE PROTEINS ENHANCING PULMONARY METASTATIC COLONISATION Article Open access 23 March 2021 ORTHOTOPIC MODEL FOR THE ANALYSIS OF MELANOMA CIRCULATING TUMOR CELLS

Article Open access 03 April 2024 IDENTIFICATION OF BACTERIA-DERIVED HLA-BOUND PEPTIDES IN MELANOMA Article 17 March 2021 REFERENCES * _Fundamental Aspects of Metastasis_ (ed. Weiss, L.)

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Scholar  * Nicolson, G. L. _et al._ in _Cell and Tissue Interactions_ (eds Burger, M. M. & Lash, J.) (Raven, New York, 1977). Google Scholar  Download references AUTHOR INFORMATION

AUTHORS AND AFFILIATIONS * Department Biochemistry, Biocenter, University of Basel, CH 4056, Basel, Switzerland TIEN-WEN TAO & MAX M. BURGER Authors * TIEN-WEN TAO View author

publications You can also search for this author inPubMed Google Scholar * MAX M. BURGER View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE TAO, TW., BURGER, M. Non-metastasising variants selected from metastasising melanoma cells. _Nature_ 270, 437–438

(1977). https://doi.org/10.1038/270437a0 Download citation * Received: 01 September 1977 * Accepted: 30 September 1977 * Issue Date: 01 December 1977 * DOI: https://doi.org/10.1038/270437a0

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