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ABSTRACT THE importance of various brain structures in the regulation of secretion of gonadotropins1–3 and the presence of steroid hormones in the cerebrospinal fluid (CSF)4–5 suggest that a

method for delivering steroids into the CSF might be useful in the control of fertility. Steroids can enter the cerebral components rapidly after intranasal administration and their

concentrations are higher than after intravenous injection6. We report here that progesterone and norethisterone given intranasally can prevent ovulation in rhesus monkeys. Access through

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EXPRESSION Article Open access 14 June 2023 REFERENCES * Anand Kumar, T. C. & Knowles, F. _Nature_ 215, 54–55 (1967). Article  ADS  Google Scholar  * Knowles, F. & Anand Kumar, T. C.

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AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Neuroendocrine Research Laboratory, Department of Anatomy, WHO Collaborating Centre for Research and Training in Human Reproduction, All India

Institute of Medical Sciences, New Delhi, 110 016, India T. C. ANAND KUMAR, G. F. X. DAVID & V. PURI Authors * T. C. ANAND KUMAR View author publications You can also search for this

author inPubMed Google Scholar * G. F. X. DAVID View author publications You can also search for this author inPubMed Google Scholar * V. PURI View author publications You can also search

for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE KUMAR, T., DAVID, G. & PURI, V. Ovulation in rhesus monkeys

suppressed by intranasal administration of progesterone and norethisterone. _Nature_ 270, 532–534 (1977). https://doi.org/10.1038/270532a0 Download citation * Received: 22 December 1976 *

Accepted: 11 October 1977 * Issue Date: 08 December 1977 * DOI: https://doi.org/10.1038/270532a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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