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ABSTRACT OPIATES stimulate prolactin secretion _in vivo_; plasma prolactin levels are increased by morphine administration in normal1 and steroid-primed male rats2, as well as in immature3

and oestrogen-treated female rats4. Met-enkephalin and _β_-endorphin were also stimulatory1–6 as were enkephalin analogues3,7,8. Naloxone or naltrexone, specific opiate antagonists, reduce

basal prolactin levels when given alone1,3,9, and block, at least partially, the effect of opiate agonists1–4,7,8. None of these drugs is active _in vitro_ when tested alone on anterior

pituitaries3 or dispersed pituitary cells2,4. However, as we have previously shown in a preliminary experiment, the inhibitory effect of dopamine on prolactin secretion _in vitro_ was

antagonised by the addition of morphine to the incubation medium10. In the present work, we have attempted to clarify further the mode of interaction of opiates with prolactin secretion. We

confirmed that morphine, Met-enkephalin and _β_-endorphin do not affect the spontaneous release of prolactin _in vitro_, but found that they suppress the inhibitory effect of dopamine on

prolactin release. We have also characterised the specificity and the kinetics of this interaction. Access through your institution Buy or subscribe This is a preview of subscription

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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS NO EVIDENCE FOR PROLACTIN’S INVOLVEMENT

IN THE POST-EJACULATORY REFRACTORY PERIOD Article Open access 04 January 2021 MOLECULAR MECHANISM OF PROLACTIN-RELEASING PEPTIDE RECOGNITION AND SIGNALING VIA ITS G PROTEIN-COUPLED RECEPTOR

Article Open access 03 September 2024 PITUITARY CROSSTALK WITH BONE, ADIPOSE TISSUE AND BRAIN Article 15 September 2023 REFERENCES * Bruni, G. F., Van Vugt, D., Marshall, S. & Meites, J.

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AUTHORS AND AFFILIATIONS * Unité 159 de Neuroendocrinologie, Centre Paul Broca de l'INSERM, 2ter rue d'Alésia, 75014, Paris, France A. ENJALBERT, M. RUBERG, S. ARANCIBIA, M. PRIAM 

& C. KORDON Authors * A. ENJALBERT View author publications You can also search for this author inPubMed Google Scholar * M. RUBERG View author publications You can also search for this

author inPubMed Google Scholar * S. ARANCIBIA View author publications You can also search for this author inPubMed Google Scholar * M. PRIAM View author publications You can also search for

this author inPubMed Google Scholar * C. KORDON View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE ENJALBERT, A., RUBERG, M., ARANCIBIA, S. _et al._ Endogenous opiates block dopamine inhibition of prolactin secretion _in vitro_. _Nature_ 280, 595–597 (1979).

https://doi.org/10.1038/280595a0 Download citation * Received: 19 February 1979 * Accepted: 02 July 1979 * Published: 01 August 1979 * Issue Date: 16 August 1979 * DOI:

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