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ABSTRACT Prostaglandins (PGs) have been implicated as possible modulators of the immune response and various inflammatory processes1–4. Various cell components of the immune system are

sources of PGs, and mitogen or antigen stimulation of human or murine lymphocytes leads to their enhanced release5–8. They are also released from various human and animal tumours9,10. Thus,

as cells of the immune system are both sensitive to and sources of PGs, these factors may be important as physiological immune regulators. For example, PGs of the E series are capable of

inhibiting many effector functions9–15. They have also been shown to inhibit the development of the humoral response16,17. Although they inhibit the proliferative response to mitogens18,19,

little is known about their effects on the development of the cell-mediated immune response to antigens. The data summarized here implicate PGs, thromboxane A2 (TXA2) and prostacyclin (PGI2)

in the regulation of cellular immune responses at the inductive phase. Some of these data have been reported in abstract form20. Access through your institution Buy or subscribe This is a

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INCREASE TISSUE CELL PROTECTION AGAINST PORE-FORMING TOXINS FROM PATHOGENIC BACTERIA Article Open access 17 February 2023 INTERLEUKIN-1 RECEPTOR-INDUCED PGE2 PRODUCTION CONTROLS

ACETYLCHOLINE-MEDIATED CARDIAC DYSFUNCTION AND MORTALITY DURING SCORPION ENVENOMATION Article Open access 28 October 2020 EFFECT OF LIPOPOLYSACCHARIDE AND POLYINOSINIC:POLYCYTIDYLIC ACID IN

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6, 243–260 (1973). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Experimental Therapeutics, Grace Cancer Drug Center, Roswell

Park Memorial Institute, New York State Department of Health, Buffalo, New York, 14263 Kam H. Leung & Enrico Mihich Authors * Kam H. Leung View author publications You can also search

for this author inPubMed Google Scholar * Enrico Mihich View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions

ABOUT THIS ARTICLE CITE THIS ARTICLE Leung, K., Mihich, E. Prostaglandin modulation of development of cell-mediated immunity in culture. _Nature_ 288, 597–600 (1980).

https://doi.org/10.1038/288597a0 Download citation * Received: 23 July 1980 * Accepted: 17 October 1980 * Issue Date: 11 December 1980 * DOI: https://doi.org/10.1038/288597a0 SHARE THIS

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