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ABSTRACT In two review articles in the 17 April issue Doolittle and Sapienza (p. 601) and Orgel and Crick (p. 604) separately suggested that much of the DNA in the genome of higher organisms

could be described as ‘selfish’. They argued that such DNA has no appreciable phenotypic effect and functions only to ensure its own self-preservation within the genome. This view point

stimulated a great deal of comment, some of which was published in the issue of 26 June (p. 617). Now the original authors have joined up with one of their critics and reassessed their ideas

in the two articles below. A further comment is added by H. K. Jain. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

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about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Doolittle, W. F. & Sapienza, C. _Nature_ 284, 601 (1980). Article  ADS  CAS  Google Scholar  *

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30, F3–F4 (1973). Article  Google Scholar  * See, for example, Proudfoot, N. _Nature_ 286, 840 (1980). Article  ADS  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * The Salk Institute, San Diego, California L.E. Orgel, F.H.C. Crick & C. Sapienza * the Department of Biochemistry, Dalhousie University, Halifax, Canada L.E. Orgel, F.H.C.

Crick & C. Sapienza Authors * L.E. Orgel View author publications You can also search for this author inPubMed Google Scholar * F.H.C. Crick View author publications You can also search

for this author inPubMed Google Scholar * C. Sapienza View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions

ABOUT THIS ARTICLE CITE THIS ARTICLE Orgel, L., Crick, F. & Sapienza, C. Selfish DNA. _Nature_ 288, 645–646 (1980). https://doi.org/10.1038/288645a0 Download citation * Issue Date: 18

December 1980 * DOI: https://doi.org/10.1038/288645a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

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