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ABSTRACT The function of the _Xenopus laevis_ ribosomal spacer has been studied _in vivo_ and by _microinjection_ of _in vitro_ mutants into _Xenopus_ oocytes. It is shown that the spacer

directs specific RNA transcripts which most probably terminate upstream of the ribosomal genes and that it is able to modulate transcription of these genes. The data lead to a model in which

the ribosomal spacer is a loading site for RNA polymerase I and spacer transcription is the driving force by which polymerase is delivered to the ribosomal gene promoter. Access through

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* Biophysics Laboratories, Portsmouth Polytechnic, St Michael's Building, White Swan Road, Portsmouth, Hampshire, PO1 2DT, UK Tom Moss * Institut für Molekularbiologie II der

Universität Zürich, 8093, Zürich, Switzerland Tom Moss Authors * Tom Moss View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Moss, T. A transcriptional function for the repetitive ribosomal spacer in _Xenopus laevis_. _Nature_ 302, 223–228 (1983).

https://doi.org/10.1038/302223a0 Download citation * Received: 28 October 1982 * Accepted: 07 January 1983 * Issue Date: 17 March 1983 * DOI: https://doi.org/10.1038/302223a0 SHARE THIS

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