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ABSTRACT STUDY DESIGN: An experimental study was conducted to evaluate the effects of methylprednisolone and MK-801 after the compressive injury of spinal cord in rats. OBJECTIVES: To

investigate the effect of methylprednisolone and non-competitive NMDA antagonist MK-801 in long-term functional outcome after spinal cord injury (SCI). METHODS: A randomized group A of

Sprague-Dawley rats were treated with MK-801 (1.0 mg/kg, _n_=10; Group A) after a compression injury. A group of methylprednisolone (MP)-treated (30 mg/kg, _n_=10; Group B) and non-treated

animals (_n_=9; Group C) were included for comparison. The functional motor outcome such as inclined plane (IP), toe spreading reflex (TSR), and modified Tarlov scale (TS) were measured in

each animal at regular time points up to 8 weeks post-treatment. Histologically the injury site was scored in four groups and immunohistochemically Wallerian Degeneration (WD), astrocytosis

and expression of β-amyloid protein was identified. RESULTS: In examining the IP data, no significant difference was recognized between the group means (_P_-value>0.5). For the TSR, there

were no differences in the group responses. For the TS, the differences were not statistically significant. Only group B showed significance in cavitation scores compared to group A

(_P_>0.0094), WD was significantly different than group C (_P_>0.03), astrocytosis was significantly higher than group A (_P_>0.001) and modest presence of β-amyloid protein.

CONCLUSION: Our data indicate that one time bolus administration of MK-801 lacks any significant effect on axonal function in chronically injured rats. Daily bolus administration of MP at 30

 mg/kg also did not ensure a better functional outcome. Immunohistochemically we have been able to show significant differences in WD, astrocytosis and small insignificant changes in

β-amyloid protein. SIMILAR CONTENT BEING VIEWED BY OTHERS THE COMBINATION TREATMENT OF METHYLPREDNISOLONE AND GROWTH FACTOR-RICH SERUM AMELIORATES THE STRUCTURAL AND FUNCTIONAL CHANGES AFTER

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ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Section of Neurosurgery, University of Nebraska Medical Center, Omaha, Nebraska, USA SS Haghighi, SK Agrawal, D Surdell Jr & R

Plambeck * College of Nursing, University of Nebraska Medical Center, Omaha, Nebraska, USA S Agrawal * Department of Veterinary Pathology, University of Missouri-Columbia, Columbia,

Missouri, USA GC Johnson & A Walker Authors * SS Haghighi View author publications You can also search for this author inPubMed Google Scholar * SK Agrawal View author publications You

can also search for this author inPubMed Google Scholar * D Surdell Jr View author publications You can also search for this author inPubMed Google Scholar * R Plambeck View author

publications You can also search for this author inPubMed Google Scholar * S Agrawal View author publications You can also search for this author inPubMed Google Scholar * GC Johnson View

author publications You can also search for this author inPubMed Google Scholar * A Walker View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Haghighi, S., Agrawal, S., Surdell, D. _et al._ Effects of methylprednisolone and MK-801 on functional recovery

after experimental chronic spinal cord injury. _Spinal Cord_ 38, 733–740 (2000). https://doi.org/10.1038/sj.sc.3101074 Download citation * Published: 12 January 2001 * Issue Date: 01

December 2000 * DOI: https://doi.org/10.1038/sj.sc.3101074 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * chronic spinal cord injury *

methylprednisolone * MK 801 * rats