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ABSTRACT Much of the differentiation of murine T cells takes place in the thymus1–6, perhaps influenced by the operation of stringent selection mechanisms whose existence has been inferred

from the high rate of thymocyte turnover in the absence of extensive emigration7–11. The origin of those 1% of total thymocytes which leave the thymus and seed the peripheral lymphoid organs

is obscure. Recent thymic emigrants are functionally and phenotypically mature12–14, and the purported greater maturity of medullary relative to cortical thymocytes is often cited as

evidence for the medullary origin of thymic emigrants15, a suggestion not without its critics16,17. To approach this question, we have now isolated a subpopulation of thymocytes expressing

high levels of a receptor that mediates the homing of blood-borne lymphocytes into peripheral lymph nodes. Surprisingly, this population of cells (1–3% of total thymocytes) is both cortical

and immunocompetent, containing approximately half of all thymic cytolytic T-lymphocyte precursors. The combination of homing receptor expression and immunocompetence makes this cortical

population ideally suited for emigration to peripheral lymphoid organs. Access through your institution Buy or subscribe This is a preview of subscription content, access via your

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS A GUIDE TO THYMIC SELECTION OF T CELLS Article 18 July 2023

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INFORMATION Author notes * Pamela J. Fink Present address: Department of Biology, M-001, University of California, San Diego, La Jolla, California, 92093, USA AUTHORS AND AFFILIATIONS *

Laboratory of Experimental Oncology, Department of Pathology, Stanford University Medical Center, Stanford, California, 94305, USA Pamela J. Fink, W. Michael Gallatin, Roger A. Reichert, 

Eugene C. Butcher & Irving L. Weissman Authors * Pamela J. Fink View author publications You can also search for this author inPubMed Google Scholar * W. Michael Gallatin View author

publications You can also search for this author inPubMed Google Scholar * Roger A. Reichert View author publications You can also search for this author inPubMed Google Scholar * Eugene C.

Butcher View author publications You can also search for this author inPubMed Google Scholar * Irving L. Weissman View author publications You can also search for this author inPubMed Google

Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fink, P., Gallatin, W., Reichert, R. _et al._ Homing receptor-bearing thymocytes, an

immunocompetent cortical subpopulation. _Nature_ 313, 233–235 (1985). https://doi.org/10.1038/313233a0 Download citation * Received: 25 June 1984 * Accepted: 10 October 1984 * Issue Date: 17

January 1985 * DOI: https://doi.org/10.1038/313233a0 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

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