Two dopamine genes related to reports of childhood retrospective inattention and conduct disorder symptoms

Two dopamine genes related to reports of childhood retrospective inattention and conduct disorder symptoms


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ABSTRACT The 7-repeat allele of the dopamine receptor D4 gene (DRD4) and the 10 repeat allele of the dopamine transporter gene (DAT1) have shown association and linkage with symptoms of


attention deficit hyperactivity disorder (ADHD) in childhood. The parents of ADHD children (clinic group, _n_ = 80 fathers and 107 mothers) and control children (control group, _n_ = 42


fathers and 51 mothers) were the focus of this study. These parents reported retrospectively on their level of ADHD Inattention and Conduct Disorder symptoms in adolescence. In analyses of


the relation of symptom levels to the DRD4 and DAT1 genotypes, fathers possessing the 7 repeat DRD4 allele had greater levels of both inattention and conduct disorder symptoms. Mothers with


the 10/10 genotype had higher levels of inattention symptoms. Thus, genetic associations found in children may be replicable in their parents. Access through your institution Buy or


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IN THE ASSOCIATIONS OF EATING DISORDERS WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER AND AUTISM SPECTRUM DISORDER Article Open access 14 November 2024 REFERENCES * Blum K, Cull, JG,


Braverman ER, Comings DE . Reward deficiency syndrome _Am Scientist_ 1996 84: 132–145 Google Scholar  * Krause K, Dresel SH, Krause J, Kung HF, Tatsch K . Increased striatal dopamine


transporter in patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography _Neurosci Lett_ 2000 285: 107–110


Article  CAS  PubMed  Google Scholar  * Giros B, Jaber M, Jones SR, Wightman RM, Caron MG . Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine


transporter _Nature_ 1996 379: 606–612 Article  CAS  PubMed  Google Scholar  * Seeman P, Madras BK . Anti-hyperactivity medication: methylphenidate and amphetamine _Mol Psychiatry_ 1998 3:


386–396 Article  CAS  PubMed  Google Scholar  * Vandenbergh DJ, Persico AM, Hawkins AL, Griffin CA, Li X, Jabs EW _et al_. Human dopamine transporter gene (DAT1) maps to chromosome 5pl15.3


and displays a VNTR _Genomics_ 1992 14: 1104–1106 Article  CAS  PubMed  Google Scholar  * Kang AM, Palmatier MA, Kidd KK . Global variation of a 40-bp VNTR in the 3′-untranslated region of


the dopamine transporter gene (SLC6A3) _Biol Psychiatry_ 1999 46: 151–160 Article  CAS  PubMed  Google Scholar  * Comings DE . Polygenic inheritance and micro/minisatellites _Mol Psychiatry_


1998 3: 21–31 Article  CAS  PubMed  Google Scholar  * Goldman HA, Jones DW, Palmour R, Hommer D, Gorey JG, Lee KS _et al_. Genotype influences in vivo dopamine transporter availability in


human striatum _Neuropsychopharmacology_ 2000 22: 133–139 Article  PubMed  Google Scholar  * Barr CL, Xu C, Kroft J, Feng Y, Wigg K, Zai G _et al_. Haplotype study of four polymorphisms at


the dopamine transporter locus confirm linkage to attention-deficit hyperactivity disorder _Biol Psychiatry (in press)_ * Cook EH Jr, Stein MA, Krasowski MD, Cox NJ, Olkon DM, Dieffer JE _et


al_. Association of attention deficit disorder and the dopamine transporter gene _Am J Hum Genet_ 1995 56: 993–998 PubMed  PubMed Central  Google Scholar  * Gill M, Daly G, Heron S, Hawi Z,


Fitzgerald M . Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism _Mol Psychiatry_ 1997 2: 311–313 Article  CAS  PubMed 


Google Scholar  * Waldman ID, Rowe DC, Abramowitz A, Kozel ST, Mohr JH, Sherman SL _et al_. Association and linkage of the dopamine transporter gene (DAT1) and attention deficit disorder in


children: heterogeneity due to diagnostic subtype and severity _Am J Hum Genet_ 1998 63: 1767–1776 Article  CAS  PubMed  PubMed Central  Google Scholar  * Daly G, Hawi Z, Fitzgerald M, Gill


M . Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children _Mol Psychiatry_ 1999 4:


192–196 Article  CAS  PubMed  Google Scholar  * Lichter JB, Barr CL, Kennedy JL, Van Tol HHM, Kidd KK, Livak JK . A hypervariable segment in the human dopamine receptor D4 (DRD4) gene _Hum


Mol Genet_ 1993 2: 767–773 Article  CAS  PubMed  Google Scholar  * Asghari V, Sanyal S, Buchaldt S, Paterson A, Jovanovic V, Van Tol HHM . Modulation of intracellular cyclic AMP levels by


different human dopamine D4 receptor varients _J Neurochem_ 1995 65: 1157–1165 Article  CAS  PubMed  Google Scholar  * Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH .


Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking _Nature Genet_ 1996 12: 81–84 Article  CAS  PubMed  Google Scholar  * Ebstein RP,


Novick O, Umansky R, Priel B, Osher Y, Blaine B _et al_. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking _Nature Genet_ 1996


12: 78–80 Article  CAS  PubMed  Google Scholar  * Paterson AD, Sunohara GA, Kennedy JL . Dopamine D4 receptor gene: novelty or nonsense _Neuropsychopharmacology_ 1999 21: 3–16 Article  CAS 


PubMed  Google Scholar  * Strobel AA, Wehr A, Michel A, Brocke B . Association between the dopamine D4 receptor (DRD4) exon III polymorphism and measures of novelty seeking in a German


population _Mol Psychiatry_ 1999 4: 378–384 Article  CAS  PubMed  Google Scholar  * LaHoste GJ, Swanson JM, Wigal SB, Glabe C, Wigal T, King N _et al_. Dopamine D4 receptor gene polymorphism


is associated with attention deficit hyperactivity disorder _Mol Psychiatry_ 1996 1: 121–124 CAS  PubMed  Google Scholar  * Faraone SV, Doyle AE, Mick E, Diederman J . Meta-analysis of the


association between the dopamine D4 gene 7-repeat allele and attention deficit hyperactivity disorder 2000 _Am J Psychiatry (in press)_ * Chang F, Kidd JR, Livak KJ, Pakstis AJ, Kidd KK .


The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus _Hum Genet_ 1996 98: 91–101 Article  CAS  PubMed  Google Scholar  * Holmes J, Payton A, Barrett JH,


Hever T, Fitzpatrick H, Trumper AL _et al_. A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficit


hyperactivity disorder _Mol Psychiatry_ 2000 5: 523–530 Article  CAS  PubMed  Google Scholar  * Pritchard JK, Stephens M, Rosenberg NA, Donnelly P . Association mapping in structured


populations _Am J Hum Genet_ 2000 67: 170–181 Article  CAS  PubMed  PubMed Central  Google Scholar  * Rowe DC, Stever C, Giedinghagen LN, Gard JMC, Cleveland HH, Terris ST _et al_. Dopamine


DRD4 receptor polymorphism and attention deficit hyperactivity disorder _Mol Psychiatry_ 1998 3: 419–426 Article  CAS  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS Supported


by a grant from the _National Longitudinal Study of Adolescent Health_ (Add Health) consortium to Rowe and by a First Award, K01-HM01818 to Waldman. Add Health was designed by J Richard Udry


and Peter Bearman and is funded by grant P01-HD31921 from the National Institute of Child Health and Human Development. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Graduate Committee in


Genetics and Division of Family Studies and Human Development, Campus Box 210033, University of Arizona, Tucson, 85721, AZ, USA D C Rowe * AOSIS Corporation, 815 W University Drive, Suite


106, Tempe, 85281, AZ, USA C Stever * Department of Molecular and Cellular Biology, University of Arizona, Tucson, 85721, AZ D Chase * Genetics and Molecular Medicine, Emory University,


Atlanta, 30322, GA, USA S Sherman * Department of Psychiatry, Emory University, Atlanta, 30322, GA, USA A Abramowitz * Department of Psychology, Emory University, Atlanta, 30322, GA, USA I D


Waldman Authors * D C Rowe View author publications You can also search for this author inPubMed Google Scholar * C Stever View author publications You can also search for this author


inPubMed Google Scholar * D Chase View author publications You can also search for this author inPubMed Google Scholar * S Sherman View author publications You can also search for this


author inPubMed Google Scholar * A Abramowitz View author publications You can also search for this author inPubMed Google Scholar * I D Waldman View author publications You can also search


for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to D C Rowe. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Rowe, D.,


Stever, C., Chase, D. _et al._ Two dopamine genes related to reports of childhood retrospective inattention and conduct disorder symptoms. _Mol Psychiatry_ 6, 429–433 (2001).


https://doi.org/10.1038/sj.mp.4000874 Download citation * Received: 17 October 2000 * Revised: 02 January 2001 * Accepted: 04 January 2001 * Published: 09 July 2001 * Issue Date: 01 July


2001 * DOI: https://doi.org/10.1038/sj.mp.4000874 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is


not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * association * dopamine transporter gene (DAT1) *


dopamine D4 receptor gene (DRD4) * attention deficit hyperactivity disorder (ADHD) * conduct disorder (CD)