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Fresh pieces of monkey ovary remain fully functional even when moved to a new site. ABSTRACT Radiation and high-dose chemotherapy may render women with cancer prematurely sterile, a

side-effect that would be avoided if ovarian tissue that had been removed before treatment could be made to function afterwards. Live offspring have been produced from transplanted ovarian

tissue in mice1 and sheep2 but not in monkeys3 or humans4,5, although sex steroid hormones are still secreted. Here we describe the successful transplantation of fresh ovarian tissue to a

different site in a monkey, which has led to the birth of a healthy female after oocyte production, fertilization and transfer to a surrogate mother. The ectopically grafted tissue functions

without surgical connection to major blood vessels and sets the stage for the transplantation of cryopreserved ovarian tissue in humans. Access through your institution Buy or subscribe

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OVARIAN CRYOPRESERVATION WITH RAPAMYCIN IMPROVES FERTILITY RESTORATION IN A MURINE ORTHOTOPIC TRANSPLANTATION MODEL Article Open access 19 March 2025 THE EFFECT OF HEMATOPOIETIC STEM CELL

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& Wolf, D. P. in _Contemporary Endocrinology: Assisted Fertilization and Nuclear Transfer in Mammals_ (eds Wolf, D. P. & Zelinski-Wooten, M. B.) 253–284 (Humana, Totowa, New Jersey,

2001) Book  Google Scholar  * Lutjen, P. et al. _Nature_ 307, 174–175 (1984). Article  ADS  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department

of Obstetrics and Gynecology, Division of Reproductive Sciences, Oregon Health & Science University, Pediatrics, Physiology and Pharmacology, Oregon National Primate Research Center,

Portland, 97201, Oregon, USA D. M. Lee, R. R. Yeoman, D. E. Battaglia, R. L. Stouffer, M. B. Zelinski-Wooten, J. W. Fanton & D. P. Wolf Authors * D. M. Lee View author publications You

can also search for this author inPubMed Google Scholar * R. R. Yeoman View author publications You can also search for this author inPubMed Google Scholar * D. E. Battaglia View author

publications You can also search for this author inPubMed Google Scholar * R. L. Stouffer View author publications You can also search for this author inPubMed Google Scholar * M. B.

Zelinski-Wooten View author publications You can also search for this author inPubMed Google Scholar * J. W. Fanton View author publications You can also search for this author inPubMed 

Google Scholar * D. P. Wolf View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to D. M. Lee. ETHICS DECLARATIONS

COMPETING INTERESTS The authors declare no competing financial interests. SUPPLEMENTARY INFORMATION SUPPLEMENTARY FIGURE a) Ovarian cortical tissue prepared for transplantation; b)

Transplantation to 3 mm subcutaneous pockets in the arm and abdomen. Ovarian tissue was placed with the cortex against the underlying muscle; c) Development of a follicle from fresh ovarian

tissue transplanted to the forearm. The inset shows the ultrasonographic appearance of the follicle. Oestradiol increased from 72 pg/ml to 575 pg/ml in venous blood from the transplanted

tissue. Progesterone also increased from 0.24 ng/ml to 1.82 ng/ml. (JPG 34 kb) SUPPLEMENTARY TABLE Follicular development, oocyte procurement, and fertilization by transplantation site. (DOC

43 kb) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lee, D., Yeoman, R., Battaglia, D. _et al._ Live birth after ovarian tissue transplant. _Nature_

428, 137–138 (2004). https://doi.org/10.1038/428137a Download citation * Issue Date: 11 March 2004 * DOI: https://doi.org/10.1038/428137a SHARE THIS ARTICLE Anyone you share the following

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