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Sir, It is often debated whether all lesions are in need of biopsy, particularly when reasonable working diagnoses can be made on good radiological imaging. We report a unique case in which

biopsy threw a different light on what was thought to be a terminal condition. CASE REPORT A 74-year-old woman initially presented to the general surgeons at another hospital with a history

of prolonged nausea and vomiting. As part of the investigations, she underwent computerised tomography (CT) of her abdomen that demonstrated a pancreatic mass (Figure 1a). It was described

as an 8-cm mass in the neck and body of the pancreas with vascular invasion of the splenic and portal veins but no associated lymphadenopathy. The diagnosis of inoperable terminal pancreatic

adenocarcinoma was made and the patient was offered palliative oncology referral with the understanding that she had at most a few months to live. Within a few weeks, she presented to the

ophthalmic department with discomfort from a rapidly enlarging left orbital swelling. (Figure 2a). She had count fingers vision and an inferotemporally displaced globe. CT scan of the orbit

(Figure 1b) was performed, demonstrating a 4-cm solid orbital mass obliterating the orbital fat but with no invasion of the globe or bone. Although likely to be an orbital metastasis from

the pancreatic adenocarcinoma, the decision to biopsy this lesion via an anterior orbitotomy was made. To our surprise, the initial histology, and subsequent diagnostic immunohistochemistry,

revealed that this lesion was in fact a high-grade diffuse B-cell non-Hodgkin's lymphoma (NHL). On the basis of this, the diagnosis was revised to extranodal pancreatic lymphoma with

orbital metastasis. She was subsequently submitted to six cycles of Pmit CEBO chemotherapy (Prednisolone, Mitoxantrone, Cyclophoshamide, Etoposide, Bleomycin, Vincristine). She had a

dramatic response with complete resolution of the orbital lesion clinically (Figure 2b) and of the pancreatic mass on CT. After 6 months, she remains in remission and has suffered few

treatment side effects. COMMENT This case, to the best of our knowledge, represents the first case of pancreatic lymphoma metastasising to the orbit in the absence of any nodal involvement,

as confirmed by CT chest, abdomen, and pelvis. Diffuse B-cell lymphoma is a high-grade tumour of lymphoreticular tissue derived from clonal expansion of B cells. It represents 20% of all NHL

and may occur either _de novo_ or from pre-existing low-grade lesions. The orbit is a rare site for dissemination of lymphoma, and 5.3% of 187 cases has been reported.1 Orbital metastasis

from pancreatic adenocarcinoma is even rarer,2 although it has been reported in a 38-years-old male in whom the orbital deposit was the presenting feature.3 Primary extranodal pancreatic

lymphoma forms less than 5% of all pancreatic tumours.4 On occasion, it has only been discovered after resection of a pancreatic mass5 and has even been known to mask as acute pancreatitis.6

Although elevated CA19-9 and SPAN-1 serum levels may throw suspicion on NHL as the diagnosis,7 there is no substitute for biopsy, as the radiological findings are not definitive.4 In total,

63–76% of elderly patients undergo complete remission to CHOP therapy8 (cyclophosphamide, doxorubicin, vincristine and prednisolone), and Pmit CEBO has been shown to be useful in

CHOP-resistant/relapsing cases. Her prognosis still remains in the balance with 5-year survival quoted somewhere between 12 and 41%.9 Clearly biopsy in this case has significantly altered

the management and subsequent prognosis, which untreated, would have been in the range of weeks to months. This case highlights that biopsy of orbital lesions can prove invaluable and should

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119(3): 634–639. Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Ophthalmology, Addenbrookes Hospital, Cambridge, UK N

Puvanachandra & C Rene Authors * N Puvanachandra View author publications You can also search for this author inPubMed Google Scholar * C Rene View author publications You can also

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Puvanachandra, N., Rene, C. A unique case of mistaken identity. _Eye_ 19, 108–110 (2005). https://doi.org/10.1038/sj.eye.6701407 Download citation * Published: 16 April 2004 * Issue Date: 01

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