Reader TTS

ABSTRACT Certain strains of Salmonella typhimurium and Escherichia coli, particularly those which are very sensitive to u.v. light, are killed when incubated with rat liver mixed function

oxidases and aflatoxin B1. UvrA or recA strains of E. coli are more susceptible than the wild-type strain, while the double mutant uvrA recA is the most sensitive strain yet tested. The

aflatoxin B1 metabolite is also able to induce reverse mutations in 2 histidine auxotrophic strains of S. typhimurium, one strain of which is reverted specifically by frame shift mutagens

and the other by agents inducing base pair substitutions. Pretreatment of rats with either 3-methylcholanthrene or benzo(a)pyrene, both inducers of liver microsomal mixed function oxidases,

did not alter the amount of lethal aflatoxin B1 metabolite formed, whereas an increase was observed after phenobarbitone pretreatment. Addition of the nucleophiles methionine, cysteine,

glutathione, sodium thiosulphate or sodium sulphide, or the epoxide hydrase inhibitor, cyclohexene oxide to the toxicity assay medium did not alter bacterial killing by the aflatoxin B1

metabolite. 2,3-Dimercaptopropanol had some protective action. Toxic metabolites were also formed when 5-methoxysterigmatocystin, O-methylsterigmatocystin, parasiticol or versicolorin A, but

not vericolorin B, were incubated with mixed function oxidases. The relationship between the metabolite of aflatoxin B1 lethal to bacteria and that which initiates liver cancer is

discussed. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to

this journal Receive 24 print issues and online access $259.00 per year only $10.79 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy

now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact

customer support SIMILAR CONTENT BEING VIEWED BY OTHERS DIFFERENTIAL GENOTOXICITY OF _POLYGONI MULTIFLORI_ IN RAT AND HUMAN: INSIGHTS FROM AMES TEST AND S9 METABOLIC ACTIVATION SYSTEM

Article Open access 13 September 2024 CO-ADMINISTRATION OF LIPOPOLYSACCHARIDE AND D-GALACTOSAMINE INDUCES GENOTOXICITY IN MOUSE LIVER Article Open access 18 January 2021 P53 TRIGGERS

MITOCHONDRIAL APOPTOSIS FOLLOWING DNA DAMAGE-DEPENDENT REPLICATION STRESS BY THE HEPATOTOXIN METHYLEUGENOL Article Open access 29 November 2022 Authors * R C Garner View author publications

You can also search for this author inPubMed Google Scholar * C M Wright View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints

and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Garner, R., Wright, C. Induction of Mutations in DNA-repair Deficient Bacteria by a Liver Microsomal Metabolite of Aflatoxin B1. _Br J

Cancer_ 28, 544–551 (1973). https://doi.org/10.1038/bjc.1973.184 Download citation * Issue Date: 01 December 1973 * DOI: https://doi.org/10.1038/bjc.1973.184 SHARE THIS ARTICLE Anyone you

share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the

Springer Nature SharedIt content-sharing initiative