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ABSTRACT A comparison has been made of the effects of the 2-nitroimidazole Ro-07-0582 on tumour growth delay after irradiation and tumour cell survival _in vitro_ after irradiation _in

vivo_. This compound has previously been shown to be a specific sensitizer of hypoxic cells. A dose of 1 mg/g body weight gave an enhancement ratio of 2-2 for both growth delay and cell

survival in a system where high pressure oxygen has been shown to have no effect. However, while the hypoxic fraction in the tumour was estimated to be less then 10% from the growth delay

curves, the survival curves gave a value in excess of 50%. This discrepancy probably reflects differences in the response of cells left in situ or removed and assayed _in vitro_. Access

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SIMILAR CONTENT BEING VIEWED BY OTHERS TRANSIENTLY HYPOXIC TUMOUR CELL TURNOVER AND RADIATION SENSITIVITY IN HUMAN TUMOUR XENOGRAFTS Article 14 January 2022 HOW THE HISTOLOGICAL STRUCTURE OF

SOME LUNG CANCERS SHAPED ALMOST 70 YEARS OF RADIOBIOLOGY Article Open access 07 November 2022 HYPOXIC MICROENVIRONMENT IN CANCER: MOLECULAR MECHANISMS AND THERAPEUTIC INTERVENTIONS Article

Open access 17 February 2023 Authors * N J McNally View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE McNally, N. The effect of an hypoxic cell sensitizer on tumour growth delay and cell survival. Implications for cell survival _in situ_ and _in vitro_. _Br J

Cancer_ 32, 610–618 (1975). https://doi.org/10.1038/bjc.1975.268 Download citation * Issue Date: 01 November 1975 * DOI: https://doi.org/10.1038/bjc.1975.268 SHARE THIS ARTICLE Anyone you

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