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ABSTRACT Sera from a small sample of adult blood donors, healthy school children and patients with lymphoma, leukaemia, non-haematologic cancer, congenital and inflammatory disorders from

Ibadan, Nigeria were screened for HTLV-I antibody by an enzyme-linked immunoabsorbent assay and confirmed by investigational Western blot. Seventy-nine of 236 positively screened samples

could not be tested for confirmation. Seropositive reactivity was observed in nine of 123 blood donors, and 3 of 46 healthy school children but banding patterns on Western blot were often

sparse. Among non-Burkitt's non Hodgkin's lymphoma patients six of 30 were HTLV-I positive including four of four with clinical features of adult T-cell leukaemia (ATL). Other

clinical conditions had a frequency of positivity indistinguishable from healthy donors. Western blot patterns ranged from strong with multiple bands, which were uncommon, to those with only

p24 and p21 envelope positive which were frequent. Given the relative paucity of clinical ATL and the unusual Western blot patterns the true rate of HTLV-I infection may be lower than

estimated. It is possible that a cross-reactive HTLV-I-like virus accounts for this pattern. Access through your institution Buy or subscribe This is a preview of subscription content,

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CELL LEUKAEMIA EARLY Article Open access 26 March 2021 AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Haematology, College of Medicine University of Ibadan, Nigeria CKO Williams

Authors * CKO Williams View author publications You can also search for this author inPubMed Google Scholar * SS Alexander View author publications You can also search for this author

inPubMed Google Scholar * A Bodner View author publications You can also search for this author inPubMed Google Scholar * A Levine View author publications You can also search for this

author inPubMed Google Scholar * C Saxinger View author publications You can also search for this author inPubMed Google Scholar * RC Gallo View author publications You can also search for

this author inPubMed Google Scholar * WA Blattner View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT

THIS ARTICLE CITE THIS ARTICLE Williams, C., Alexander, S., Bodner, A. _et al._ Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria. _Br J Cancer_ 67, 783–786 (1993).

https://doi.org/10.1038/bjc.1993.142 Download citation * Issue Date: 01 April 1993 * DOI: https://doi.org/10.1038/bjc.1993.142 SHARE THIS ARTICLE Anyone you share the following link with

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