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ABSTRACT The effects of a combination chemotherapy (CAV-PVP) consisting of cyclophosphamide, doxorubicin, hydrochloride (dox) and vincristine (CAV) alternating with cisplatin and etoposide

(PVP) on peripheral blood hematopoietic progenitor cells (PBHPs) were studied in five patients with small cell lung cancer (SCLC). The kinetics of the CFU-GM levels were different during the

CAV and PVP phases. None of the five patients displayed a rebound increase in the level of peripheral blood CFU-GM during the CAV phase. In contrast, all five patients displayed a rebound

increase in peripheral blood CFU-GM levels during the PVP phase of the alternative combination chemotherapy (3-5 weeks after the initiation of PVP regimen). These findings indicate the

optimal timing for leukapheresis to obtain PBHPs in SCLC patients which have been treated with an alternating combination chemotherapy consisting of CAV-PVP. Access through your institution

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AFFILIATIONS * Third Department of Internal Medicine, University of Tokushima School of Medicine, Japan E Shimizu Authors * E Shimizu View author publications You can also search for this

author inPubMed Google Scholar * A Yamamoto View author publications You can also search for this author inPubMed Google Scholar * Y Takahashi View author publications You can also search

for this author inPubMed Google Scholar * K Maniwa View author publications You can also search for this author inPubMed Google Scholar * S Yoshida View author publications You can also

search for this author inPubMed Google Scholar * J Mukai View author publications You can also search for this author inPubMed Google Scholar * Y Takaue View author publications You can also

search for this author inPubMed Google Scholar * T Ogura View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions

ABOUT THIS ARTICLE CITE THIS ARTICLE Shimizu, E., Yamamoto, A., Takahashi, Y. _et al._ Effect of alternating combination chemotherapy consisting of cyclophosphamide, doxorubicin,

vincristine, cisplatin, and etoposide for small cell lung cancer on hematopoietic progenitors in the peripheral blood. _Br J Cancer_ 67, 798–800 (1993). https://doi.org/10.1038/bjc.1993.145

Download citation * Issue Date: 01 April 1993 * DOI: https://doi.org/10.1038/bjc.1993.145 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get

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