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ABSTRACT Hyperbaric oxygen (HBO) has been proposed to reduce tumour hypoxia by increasing the amount of dissolved oxygen in the plasma. That this actually occurs has not been verified

experimentally. This study was performed to explore changes in tumour oxygenation induced by treatment with normobaric and hyperbaric oxygen and carbogen. R3230Ac mammary adenocarcinomas

were implanted into Fisher 344 rats. Arterial blood gases, blood pressure and heart rate were monitored. Tumour oxygenation was measured polarographically in five sets of animals. They

received either normobaric 100% oxygen, hyperbaric (3 atmospheres; atm) 100% oxygen, normobaric carbogen or hyperbaric (3 atm) carbogen (HBC) +/- bretylium. HBO reduced the mean level of low

pO2 values (< 5 mmHg) from 0.49 to 0.07 (P = 0.0003) and increased the average median pO2 from 8 mmHg to 55 mmHg (P = 0.001). HBC reduced the level of low pO2 values from 0.82 to 0.51 (P

= 0.002) an increased median pO2 from 2 mmHg to 6 mmHg (P = 0.05). Normobaric oxygen and carbogen did not change tumour oxygenation significantly. Sympathetic blockade with bretylium before

HBC exposure improved oxygenation significantly more than HBC alone (low pO2 0.55-0.17, median pO2 4-17 mmHg). HBO and hyperbaric carbogen improved tumour oxygenation in this model, while

normobaric oxygen or carbogen had no effect. Sympathetic-mediated vasoconstriction during hyperbaric carbogen caused it to be less effective than HBO. This mechanism also appeared to operate

during normobaric carbogen breathing. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through

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Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS HYPERBARIC OXYGEN SUPPRESSED TUMOR PROGRESSION THROUGH THE IMPROVEMENT OF TUMOR HYPOXIA AND INDUCTION OF TUMOR

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ON OXYGEN CONSUMPTION Article Open access 17 June 2021 TRANSIENTLY HYPOXIC TUMOUR CELL TURNOVER AND RADIATION SENSITIVITY IN HUMAN TUMOUR XENOGRAFTS Article 14 January 2022 AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Department of Radiation Oncology, Duke University Medical Center, Durham, 27710, North Carolina, USA DM Brizel Authors * DM Brizel View author

publications You can also search for this author inPubMed Google Scholar * S Lin View author publications You can also search for this author inPubMed Google Scholar * JL Johnson View author

publications You can also search for this author inPubMed Google Scholar * J Brooks View author publications You can also search for this author inPubMed Google Scholar * MW Dewhirst View

author publications You can also search for this author inPubMed Google Scholar * CA Piantadosi View author publications You can also search for this author inPubMed Google Scholar RIGHTS

AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Brizel, D., Lin, S., Johnson, J. _et al._ The mechanisms by which hyperbaric oxygen and carbogen improve tumour

oxygenation. _Br J Cancer_ 72, 1120–1124 (1995). https://doi.org/10.1038/bjc.1995.474 Download citation * Issue Date: 01 November 1995 * DOI: https://doi.org/10.1038/bjc.1995.474 SHARE THIS

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