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ABSTRACT Allogeneic hematopoietic cell transplantation is associated with late adverse effects of therapy, including secondary solid cancers. Most reports address risk factors; however,

outcomes after secondary solid cancer development are incompletely described. Our objective was to estimate survival probabilities for transplant recipients dependent on secondary solid

cancer subtype. We used a previously identified and published cohort who developed secondary solid cancers following allogeneic transplant. Follow-up for these 112 previously identified

patients was extended and their survival probabilities were studied. Median duration of follow-up from the development of secondary cancer for survivors was 11.9 years (range: 0.8–23.4) and

75% were followed >7.0 years. The 5- and 10-year overall survival probabilities were 50% (95% confidence interval (CI): 41–60) and 46% (95% CI: 37–57), respectively. Overall survival

varied by secondary cancer type. Secondary cancer was the cause of death in most patients who died following development of melanoma, central nervous system, oral cavity, thyroid, lung,

lower gastrointestinal tract and bone cancers. Extended follow-up allowed for the most comprehensive longitudinal evaluation to date of this rare condition. These findings will enhance

clinicians' ability to predict outcomes and counsel transplant survivors who develop secondary solid cancers. Access through your institution Buy or subscribe This is a preview of

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HEMATOPOIETIC STEM CELL TRANSPLANT ON THE DEVELOPMENT OF SECOND PRIMARY MALIGNANCIES IN MULTIPLE MYELOMA PATIENTS Article Open access 07 January 2021 LONG-TERM OUTCOMES OF ALLOGENEIC STEM

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http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014. Download references ACKNOWLEDGEMENTS We thank Drs M Kelly, R

Tower, J Panepinto, A Brandow, M Eapen, D Margolis, A Maguire and D Mulrooney for their support of and insight into this project. The CIBMTR is supported by Public Health Service

Grant/Cooperative Agreement U24-CA076518 from the National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI) and the National Institute of Allergy and Infectious

Diseases (NIAID); a Grant/Cooperative Agreement 5U10HL069294 from NHLBI and NCI; a contract HHSH250201200016C with Health Resources and Services Administration (HRSA/DHHS); two Grants

N00014-12-1-0142 and N00014-13-1-0039 from the Office of Naval Research. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Cancer Survivorship, Department of Oncology, St Jude

Children’s Research Hospital, Memphis, TN, USA M J Ehrhardt * Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI, USA R Brazauskas *

Department of Medicine, CIBMTR (Center for International Blood and Marrow Transplant Research), Froedtert and the Medical College of Wisconsin Clinical Cancer Center, Milwaukee, WI, USA R

Brazauskas, W He, J D Rizzo & B E Shaw Authors * M J Ehrhardt View author publications You can also search for this author inPubMed Google Scholar * R Brazauskas View author publications

You can also search for this author inPubMed Google Scholar * W He View author publications You can also search for this author inPubMed Google Scholar * J D Rizzo View author publications

You can also search for this author inPubMed Google Scholar * B E Shaw View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR

Correspondence to B E Shaw. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE Ehrhardt, M., Brazauskas, R., He, W. _et al._ Survival of patients who develop solid tumors following hematopoietic stem cell transplantation. _Bone Marrow Transplant_ 51, 83–88

(2016). https://doi.org/10.1038/bmt.2015.203 Download citation * Received: 09 January 2015 * Revised: 04 June 2015 * Accepted: 17 June 2015 * Published: 14 September 2015 * Issue Date:

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