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ABSTRACT BACKGROUND/OBJECTIVES: Rates of obesity are greatest in middle age. Obesity is associated with altered activity of brain networks sensing food-related stimuli and internal signals

of energy balance, which modulate eating behaviour. The impact of healthy mid-life ageing on these processes has not been characterised. We therefore aimed to investigate changes in brain

responses to food cues, and the modulatory effect of meal ingestion on such evoked neural activity, from young adulthood to middle age. SUBJECTS/METHODS: Twenty-four healthy, right-handed

subjects, aged 19.5–52.6 years, were studied on separate days after an overnight fast, randomly receiving 50 ml water or 554 kcal mixed meal before functional brain magnetic resonance

imaging while viewing visual food cues. RESULTS: Across the group, meal ingestion reduced food cue-evoked activity of amygdala, putamen, insula and thalamus, and increased activity in

precuneus and bilateral parietal cortex. Corrected for body mass index, ageing was associated with decreasing food cue-evoked activation of right dorsolateral prefrontal cortex (DLPFC) and

precuneus, and increasing activation of left ventrolateral prefrontal cortex (VLPFC), bilateral temporal lobe and posterior cingulate in the fasted state. Ageing was also positively

associated with the difference in food cue-evoked activation between fed and fasted states in the right DLPFC, bilateral amygdala and striatum, and negatively associated with that of the

left orbitofrontal cortex and VLPFC, superior frontal gyrus, left middle and temporal gyri, posterior cingulate and precuneus. There was an overall tendency towards decreasing modulatory

effects of prior meal ingestion on food cue-evoked regional brain activity with increasing age. CONCLUSIONS: Healthy ageing to middle age is associated with diminishing sensitivity to meal

ingestion of visual food cue-evoked activity in brain regions that represent the salience of food and direct food-associated behaviour. Reduced satiety sensing may have a role in the greater

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our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS NEURAL UNDERPINNINGS OF FOOD CHOICE AND CONSUMPTION IN OBESITY Article 05 October 2021 HOMEOSTASIS AND FOOD CRAVING

IN OBESITY: A FUNCTIONAL MRI STUDY Article Open access 17 August 2021 SEX DIFFERENCES IN CENTRAL INSULIN ACTION: EFFECT OF INTRANASAL INSULIN ON NEURAL FOOD CUE REACTIVITY IN ADULTS WITH

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Hospital Charity, Diabetes UK and the UK Department of Health via the National Institute for Health Research comprehensive Biomedical Research Centre award to Guy’s and St Thomas’ Hospitals

Trust in partnership with King’s College London and King’s College Hospital NHS Foundation Trust. We thank research nurses Bula Wilson and Andrew Pernet, the radiographers, and the

volunteers who took part. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Diabetes Research Group, School of Medicine, King’s College London, London, UK Y S Cheah, S Lee, G Ashoor, Y Nathan 

& S A Amiel * Centre for Neuroimaging Sciences, Institute of Psychiatry, King’s College London, London, UK S Lee, L J Reed, F O Zelaya & M J Brammer * Division of Brain Sciences,

Centre for Mental Health, Imperial College London, London, UK L J Reed Authors * Y S Cheah View author publications You can also search for this author inPubMed Google Scholar * S Lee View

author publications You can also search for this author inPubMed Google Scholar * G Ashoor View author publications You can also search for this author inPubMed Google Scholar * Y Nathan

View author publications You can also search for this author inPubMed Google Scholar * L J Reed View author publications You can also search for this author inPubMed Google Scholar * F O

Zelaya View author publications You can also search for this author inPubMed Google Scholar * M J Brammer View author publications You can also search for this author inPubMed Google Scholar

* S A Amiel View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Y S Cheah. ETHICS DECLARATIONS COMPETING INTERESTS

The authors declare no conflict of interest. ADDITIONAL INFORMATION Supplementary Information accompanies this paper on International Journal of Obesity website SUPPLEMENTARY INFORMATION

SUPPLEMENTARY MATERIAL (PDF 975 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Cheah, Y., Lee, S., Ashoor, G. _et al._ Ageing diminishes the

modulation of human brain responses to visual food cues by meal ingestion. _Int J Obes_ 38, 1186–1192 (2014). https://doi.org/10.1038/ijo.2013.237 Download citation * Received: 22 July 2013

* Revised: 22 November 2013 * Accepted: 10 December 2013 * Published: 16 December 2013 * Issue Date: September 2014 * DOI: https://doi.org/10.1038/ijo.2013.237 SHARE THIS ARTICLE Anyone you

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Springer Nature SharedIt content-sharing initiative KEYWORDS * eating behaviour * appetite * ageing * dorsolateral prefrontal cortex * orbitofrontal cortex * striatum