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SUMMARY We have collected data on 111 cases of malignant tumors arising in patients with congenital, mostly hereditary bone dysplasias by means of a questionnaire. In addition to such

well-recognized associations as: chondrosarcoma in osteochondroma, sarcomas in fibrous dysplasia, chondrosarcoma in enchondromatoses, and chondrosarcoma in Maffucci syndrome, there were

several combinations of tumor and bone dysplasia which have not been well documented. These combinations included three cases of osteosarcoma arising in osteogenesis imperfecta tarda, 3

cases of osteosarcoma in Rothmund-Thomson syndrome, a case of osteosarcoma and a case of chondrosarcoma in spondyloepiphyseal dysplasia tarda, 2 cases of lymphoma in metaphyseal

chondrodysplasia, type McKusick, and a case of chondrosarcoma in Gardner syndrome. While the coexistence of malignancy and bone dysplasia may in some combinations be only coincidental, in

some other combinations, an interrelationship of the two conditions seems to be possible. The possibilities of such relationship are briefly discussed. SIMILAR CONTENT BEING VIEWED BY OTHERS

CALCIFIED CHONDROID MESENCHYMAL NEOPLASMS WITH _FN1_-RECEPTOR TYROSINE KINASE GENE FUSIONS INCLUDING _FGFR2, FGFR1, MERTK, NTRK1_, AND _TEK_: A MOLECULAR AND CLINICOPATHOLOGIC ANALYSIS

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CLINICOPATHOLOGIC CHARACTERIZATION OF MALIGNANT CHONDROBLASTOMA: A NEOPLASM WITH LOCALLY AGGRESSIVE BEHAVIOR AND METASTATIC POTENTIAL THAT CLOSELY MIMICS CHONDROBLASTOMA-LIKE OSTEOSARCOMA

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Surgery, Mie University School of Medicine, 514, Tsu, Japan Toyoshi Tsuruta & Yoshio Ogihara Authors * Toyoshi Tsuruta View author publications You can also search for this author

inPubMed Google Scholar * Yoshio Ogihara View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Tsuruta, T., Ogihara, Y. Malignant tumors arising in patients with congenital bone diseases —Investigation by a questionnaire. _Jap J Human Genet_ 29, 31–37 (1984).

https://doi.org/10.1007/BF01876755 Download citation * Received: 16 September 1983 * Revised: 27 January 1984 * Issue Date: March 1984 * DOI: https://doi.org/10.1007/BF01876755 SHARE THIS

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Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Lymphoma * Cancer Research * Sarcoma * Malignant Tumor * Osteosarcoma