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ABSTRACT Hypertension in pregnancy is an emerging sex-specific risk factor for cardiovascular disease and may lead to more severe hypertension after pregnancy. The objectives of this study

were to investigate the frequency of pregnancy-related hypertension among patients referred to a hypertension clinic and its association with the severity of hypertension and evidence of

end-organ damage. In this cross-sectional study, women with hypertension were submitted to a systematic clinical evaluation. The occurrence of pregnancy-related hypertension was investigated

by questionnaire. The association between pregnancy-related hypertension and severity of hypertension (stage 2 according to Seventh Report of the Joint National Committee on Prevention,

Detection, Evaluation, and Treatment of High Blood Pressure (JNC VII)) and end-organ damage was assessed in a logistic regression model. The mean age, systolic and diastolic blood pressure

and body mass index (BMI) of the 768 women examined were 51.6±12.7 years, 158.2±26.6 mm Hg, 93.8±14.3 mm Hg and 29.4±5.6 kg/m2, respectively. The proportion of women with pregnancy-related

hypertension was 32.9%. It was significantly associated with hypertension at stage 2 (OR: 1.60, 95% CI: 1.14–2.24; _P_=0.01) after controlling for confounders. The occurrence of a

pregnancy-related hypertension was not associated with evidence of optic fundi abnormalities, left ventricular hypertrophy or abnormalities in kidney function. In conclusion,

pregnancy-related hypertension is frequent in women referred to a hypertension clinic, and is associated with severe hypertension but not with evidence of end-organ damage. Access through

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funded by CNPq and FAPERGS, Brazil. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Clinical Pharmacology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande

do Sul, Porto Alegre, Brazil L B Moreira * Division of Cardiology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil M Gus, G Nunes, C B C

Gonçalves, J Martins, M Wiehe & F D Fuchs Authors * L B Moreira View author publications You can also search for this author inPubMed Google Scholar * M Gus View author publications You

can also search for this author inPubMed Google Scholar * G Nunes View author publications You can also search for this author inPubMed Google Scholar * C B C Gonçalves View author

publications You can also search for this author inPubMed Google Scholar * J Martins View author publications You can also search for this author inPubMed Google Scholar * M Wiehe View

author publications You can also search for this author inPubMed Google Scholar * F D Fuchs View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING

AUTHOR Correspondence to L B Moreira. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Moreira, L., Gus, M., Nunes, G. _et al._ Association between

pregnancy-related hypertension and severity of hypertension. _J Hum Hypertens_ 23, 415–419 (2009). https://doi.org/10.1038/jhh.2008.140 Download citation * Received: 31 May 2008 * Revised:

14 October 2008 * Accepted: 23 October 2008 * Published: 20 November 2008 * Issue Date: June 2009 * DOI: https://doi.org/10.1038/jhh.2008.140 SHARE THIS ARTICLE Anyone you share the

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Nature SharedIt content-sharing initiative KEYWORDS * severe hypertension * cardiovascular disease * pregnancy * blood pressure * end-organ damage