Reader TTS

Access through your institution Buy or subscribe A recent paper in this Journal reported evidence for the involvement of a novel imprinted gene on chromosome 2p12, the _leucine-rich repeat

transmembrane neuronal 1_ (_LRRTM1_) gene, in the development of schizophrenia/schizoaffective disorder and human handedness. Francks _et al._1 found a three-marker haplotype upstream of

_LRRTM1_ to be associated with schizophrenia when inherited paternally. It is interesting that the same haplotype was also found to be paternally associated with handedness in a sample of

reading-disabled sibships, implying the existence of specific imprinting effects on human brain asymmetry. We tested Francks _et al._'s hypotheses in large independent samples of (i)

schizophrenia and (ii) dyslexia patients with handedness information. We genotyped the three markers that define the paternally overtransmitted haplotype in the Francks _et al._ study,

rs1446109–rs1007371–rs723524, in 180 parent–offspring trios with schizophrenia. Assuming the hypothesis that true parent-of-origin effects detected in trios should also result in allelic

association in case–control studies,1 we additionally genotyped these markers in 673 patients with schizophrenia (358 males/315 females) and 1060 controls (566 males/494 females).

Individuals, who were recruited from consecutive admissions to the Department of Psychiatry at the University of Bonn, Germany, were of German descent, and had given written informed consent

to participate in this study. Diagnoses were made according to Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) criteria2 on the basis of a Structured Clinical Interview

for DSM-Disorders (SCID-I) interview,3 review of medical records and use of the family history method. The Operational Criteria for Psychotic and Affective Illness (OPCRIT) system was also

used.4 Genotyping on DNA samples was carried out using Sequenom's iPlex assay (Sequenom Inc., San Diego, CA, USA), according to the manufacturer's protocol. This is a preview of

subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only

$21.58 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout

ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Francks C, Maegawa S, Lauren J, Abrahams BS,

Velayos-Baeza A, Medland SE _et al_. _Mol Psychiatry_ 2007; 12: 1129–1139, 1057. (e-pub ahead of print 31 July 2007). Article  CAS  Google Scholar  * American Psychiatric Association CoNaS.

American Psychiatric Association: Washington, DC, USA, 1994. * First MB, Spitzer RL, Gibbon M, Williams JBW . _Clinical Interview for DSM-IV Axis I Disorders_. Patient edition. Biometrics

Research Department, New York State Psychiatric Institute: New York, NY, USA, 1997. Google Scholar  * Farmer AE, Wessely S, Castle D, McGuffin P . _Br J Psychiatry_ 1992; 161: 824–830.

Article  CAS  Google Scholar  * Becker T, Knapp M . _Genet Epidemiol_ 2004; 27: 21–32. Article  Google Scholar  * Schulte-Körne G, Ziegler A, Deimel W, Schumacher J, Plume E, Bachmann C _et

al_. _Ann Hum Genet_ 2007; 71 (Part 2): 160–175. Article  Google Scholar  * Abecasis GR, Cardon LR, Cookson WO . _Am J Hum Genet_ 2000; 66: 279–292. Article  CAS  Google Scholar  Download

references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany K U Ludwig, M Mattheisen, T W Mühleisen, M M

Nöthen, P Hoffmann & S Cichon * Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany M Mattheisen * Max-Planck Institute of Psychiatry, Munich,

Germany D Roeske & B Müller-Myhsok * Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany C Schmäl, R Breuer & M Rietschel *

Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Munich, Germany G Schulte-Körne * Institute of Human Genetics, University of Bonn, Bonn, Germany

M M Nöthen, P Hoffmann & S Cichon Authors * K U Ludwig View author publications You can also search for this author inPubMed Google Scholar * M Mattheisen View author publications You

can also search for this author inPubMed Google Scholar * T W Mühleisen View author publications You can also search for this author inPubMed Google Scholar * D Roeske View author

publications You can also search for this author inPubMed Google Scholar * C Schmäl View author publications You can also search for this author inPubMed Google Scholar * R Breuer View

author publications You can also search for this author inPubMed Google Scholar * G Schulte-Körne View author publications You can also search for this author inPubMed Google Scholar * B

Müller-Myhsok View author publications You can also search for this author inPubMed Google Scholar * M M Nöthen View author publications You can also search for this author inPubMed Google

Scholar * P Hoffmann View author publications You can also search for this author inPubMed Google Scholar * M Rietschel View author publications You can also search for this author inPubMed 

Google Scholar * S Cichon View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to S Cichon. RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ludwig, K., Mattheisen, M., Mühleisen, T. _et al._ Supporting evidence for _LRRTM1_ imprinting effects in schizophrenia. _Mol

Psychiatry_ 14, 743–745 (2009). https://doi.org/10.1038/mp.2009.28 Download citation * Published: 23 July 2009 * Issue Date: August 2009 * DOI: https://doi.org/10.1038/mp.2009.28 SHARE THIS

ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard

Provided by the Springer Nature SharedIt content-sharing initiative