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ABSTRACT Replying to: K. Ko _et al._ _Nature_ 465, 10.1038/nature09089 (2010) Ko _et al._1 challenge our description of human adult germline stem cells (haGSCs)2, indicating that we have

instead cultured testis fibroblasts. However, they do not follow the experimental procedures we describe2 and so fail to reproduce our findings. Access through your institution Buy or

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GERMLINE STEM CELLS IN HUMAN Article Open access 02 October 2022 GENOMIC STABILITY OF MOUSE SPERMATOGONIAL STEM CELLS IN VITRO Article Open access 17 December 2021 THE MUTATIONAL LANDSCAPE

OF HUMAN SOMATIC AND GERMLINE CELLS Article 25 August 2021 REFERENCES * Ko, K. et al. Human adult germline stem cells in question. _Nature_ 465 10.1038/nature09089 (2010) * Conrad, S. et al.

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* Golestaneh, N. et al. Pluripotent stem cells derived from adult human testes. _Stem Cells Dev._ 18, 1115–1126 (2009) Article  Google Scholar  * Kossack, N. et al. Isolation and

characterization of pluripotent human spermatogonial stem cell-derived cells. _Stem Cells_ 27, 138–149 (2009) Article  CAS  Google Scholar  * Mizrak, S. C. et al. Embryonic stem cell-like

cells derived from adult human testis. _Hum. Reprod._ 25, 158–167 (2010) Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of

Experimental Embryology, *Institute of Anatomy, Österbergstraße 3, 72074 Tübingen, Germany, Sabine Conrad, Tina Wiesner, Lothar Just & Thomas Skutella * Department of Cellular

Neurobiology, †Institute of Anatomy, Österbergstraße 3, 72074 Tübingen, Germany, Ulrich Mattheus, Andreas Mack & Hans-Joachim Wagner * ‡Department of Urology, University Clinic Tübingen,

Hoppe-Seyler-Straße 3, Tübingen 72076, Germany, Markus Renninger, Jörg Hennenlotter, Karl-Dietrich Sievert & Arnulf Stenzl * §Institute of Anthropology and Human Genetics, Microarray

Facility, University Clinic, Calwerstraße 7, 72076 Tübingen, Germany, Michael Bonin * ‖ZMF Research Laboratories, University Clinic Tübingen, Waldhörnlestraße 22, 72072 Tübingen, Germany,

Wilhelm Aicher * ¶Center for Regenerative Biology and Medicine (ZRM), Paul-Ehrlich-Straße 15, 72076 Tübingen, Germany, Wilhelm Aicher & Thomas Skutella * #Department of Internal Medicine

II, University Clinic Tübingen, Otfried-Müller-Straße 10, 72076 Tübingen, Germany, Hans-Jörg Bühring * Stem Cell Biology Laboratory, Wolfson Centre for Age-Related Diseases, King's

College London, King's College, London SE1 1UL, UK Stephen Minger * **Institute of Neurophysiology, University of Cologne, Robert-Koch-Straße 39, 50931 Cologne, Germany., Matthias

Matzkies, Michael Reppel & Jürgen Hescheler Authors * Sabine Conrad View author publications You can also search for this author inPubMed Google Scholar * Markus Renninger View author

publications You can also search for this author inPubMed Google Scholar * Jörg Hennenlotter View author publications You can also search for this author inPubMed Google Scholar * Tina

Wiesner View author publications You can also search for this author inPubMed Google Scholar * Lothar Just View author publications You can also search for this author inPubMed Google

Scholar * Michael Bonin View author publications You can also search for this author inPubMed Google Scholar * Wilhelm Aicher View author publications You can also search for this author

inPubMed Google Scholar * Hans-Jörg Bühring View author publications You can also search for this author inPubMed Google Scholar * Ulrich Mattheus View author publications You can also

search for this author inPubMed Google Scholar * Andreas Mack View author publications You can also search for this author inPubMed Google Scholar * Hans-Joachim Wagner View author

publications You can also search for this author inPubMed Google Scholar * Stephen Minger View author publications You can also search for this author inPubMed Google Scholar * Matthias

Matzkies View author publications You can also search for this author inPubMed Google Scholar * Michael Reppel View author publications You can also search for this author inPubMed Google

Scholar * Jürgen Hescheler View author publications You can also search for this author inPubMed Google Scholar * Karl-Dietrich Sievert View author publications You can also search for this

author inPubMed Google Scholar * Arnulf Stenzl View author publications You can also search for this author inPubMed Google Scholar * Thomas Skutella View author publications You can also

search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Thomas Skutella. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial

interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Conrad, S., Renninger, M., Hennenlotter, J. _et al._ _Conrad_ et al. _reply_. _Nature_ 465, E3

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