Reader TTS

Lysosomes are the main degradative compartment in cells, but they are also involved in cell-death pathways. Studies using existing drugs show that lysosomes are excellent pharmacological

targets for selectively destroying cancer cells. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution RELEVANT ARTICLES

Open Access articles citing this article. * NANOPARTICLE CORE STABILITY AND SURFACE FUNCTIONALIZATION DRIVE THE MTOR SIGNALING PATHWAY IN HEPATOCELLULAR CELL LINES * Mariia Lunova * , Andrey

Prokhorov *  … Alexandr Dejneka _Scientific Reports_ Open Access 22 November 2017 * CRYSTAL STRUCTURE OF MAMMALIAN ACID SPHINGOMYELINASE * Alexei Gorelik * , Katalin Illes *  … Bhushan

Nagar _Nature Communications_ Open Access 20 July 2016 ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 51 print issues and online access $199.00 per year

only $3.90 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during

checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support NOTES * *This News & Views article was published online

on 2 October 2013. REFERENCES * Petersen, N. H. T. et al. _Cancer Cell_ 24, 379–393 (2013). Article  CAS  Google Scholar  * Saftig, P. & Klumperman, J. _Nature Rev. Mol. Cell Biol._ 10,

623–635 (2009). Article  CAS  Google Scholar  * Mohamed, M. M. & Sloane, B. F. _Nature Rev. Cancer_ 6, 764–775 (2006). Article  CAS  Google Scholar  * Boya, P. & Kroemer, G.

_Oncogene_ 27, 6434–6451 (2008). Article  CAS  Google Scholar  * Fehrenbacher, N. et al. _Cancer Res._ 68, 6623–6633 (2008). Article  CAS  Google Scholar  * Kirkegaard, T. et al. _Nature_

463, 549–553 (2010). Article  ADS  CAS  Google Scholar  * Linke, T. et al. _Biol. Chem._ 382, 283–290 (2001). Article  CAS  Google Scholar  * Hurwitz, R., Ferlinz, K. & Sandhoff, K.

_Biol. Chem._ 375, 447–450 (1994). CAS  Google Scholar  * Kornhuber, J. et al. _Cell Physiol. Biochem._ 26, 9–20 (2010). Article  CAS  Google Scholar  * Abdul-Hammed, M. et al. _J. Lipid

Res._ 51, 1747–1760 (2010). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Paul Saftig is at the Biochemisches Institut, Christian

Albrechts-Universität Kiel, 24118 Kiel, Germany., Paul Saftig * Konrad Sandhoff is at the Life and Medical Sciences Institute, Universität Bonn, 53121 Bonn, Germany., Konrad Sandhoff Authors

* Paul Saftig View author publications You can also search for this author inPubMed Google Scholar * Konrad Sandhoff View author publications You can also search for this author inPubMed 

Google Scholar CORRESPONDING AUTHOR Correspondence to Paul Saftig. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Saftig, P., Sandhoff, K. Killing from

the inside. _Nature_ 502, 312–313 (2013). https://doi.org/10.1038/nature12692 Download citation * Published: 02 October 2013 * Issue Date: 17 October 2013 * DOI:

https://doi.org/10.1038/nature12692 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently

available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative