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Access through your institution Buy or subscribe To the editor: Genome sequencing has transformed biomedical research, but it is only the first step toward understanding biological systems.

Subsequent steps include the determination of three-dimensional (3D) structures and functions for all proteins, and the study of networks. Although the contribution of structural genomics to

accelerating the acquisition of experimental structures of proteins is undoubted, certain protein families have been more tractable to high-throughput approaches than others. Here, we

analyze a database of experimental structures and use a concept termed 'novel leverage' to measure the impact of structural genomics in providing new structural knowledge. This is

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Lander, E.S. et al. _Nature_ 409,

860–921 (2001). Article  CAS  Google Scholar  * Terwilliger, T.C. _Nat. Struct. Biol._ 7 Suppl, 935–939 (2000). Article  CAS  Google Scholar  * Berman, H.M. et al. _Nucleic Acids Res._ 28,

235–242 (2000). Article  CAS  Google Scholar  * Heinemann, U. _Nat. Struct. Biol._ 7 Suppl, 940–942 (2000). Article  CAS  Google Scholar  * Yokoyama, S. et al. _Nat. Struct. Biol._ 7 Suppl,

943–945 (2000). Article  CAS  Google Scholar  * Chandonia, J.M. & Brenner, S.E. _Science_ 311, 347–351 (2006). Article  CAS  Google Scholar  * Baker, D. & Sali, A. _Science_ 294,

93–96 (2001). Article  CAS  Google Scholar  * Mirkovic, N., Li, Z., Parnassa, A. & Murray, D. _Proteins_ 66, 766–777 (2007). Article  CAS  Google Scholar  * Altschul, S.F. et al.

_Nucleic Acids Res._ 25, 3389–3402 (1997). Article  CAS  Google Scholar  * Bairoch, A. et al. _Nucleic Acids Res._ 33 Database Issue, D154–D159 (2005). Article  CAS  Google Scholar  *

Venter, J.C. et al. _Science_ 304, 66–74 (2004). Article  CAS  Google Scholar  * Xing, Y. et al. _J. Biol. Chem._ 279, 30662–30669 (2004). Article  CAS  Google Scholar  Download references

ACKNOWLEDGEMENTS This work was supported by a grant from the Protein Structure Initiative (PSI) of the National Institute for General Medicine at the National Institutes of Health (NIH

U54-GM074958-01). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, 10032, New York,

USA Jinfeng Liu & Burkhard Rost * Columbia University Center for Computational Biology and Bioinformatics (C2B2), 1130 St. Nicholas Ave., New York, 10032, New York, USA Jinfeng Liu &

 Burkhard Rost * Northeast Structural Genomics Consortium (NESG), Columbia University, 1130 St. Nicholas Ave., New York, 10032, New York, USA Jinfeng Liu & Burkhard Rost * Department of

Bioinformatics, Genentech, Inc., 1 DNA Way, S. San Francisco, California, 94080, USA Jinfeng Liu * and Department of Biochemistry, Center for Advanced Biotechnology and Medicine (CABM),

Rutgers University, Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, 08854, New Jersey, USA Gaetano T Montelione * Department of Molecular Biology and Biochemistry, Northeast

Structural Genomics Consortium (NESG), Rutgers University, 679 Hoes Lane, Piscataway, 08854, New Jersey, USA Gaetano T Montelione Authors * Jinfeng Liu View author publications You can also

search for this author inPubMed Google Scholar * Gaetano T Montelione View author publications You can also search for this author inPubMed Google Scholar * Burkhard Rost View author

publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Jinfeng Liu. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no

competing financial interests. SUPPLEMENTARY INFORMATION SUPPLEMENTARY SUPPLEMENTARY TEXT AND FIGURES (PDF 214 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE Liu, J., Montelione, G. & Rost, B. Novel leverage of structural genomics. _Nat Biotechnol_ 25, 849–851 (2007). https://doi.org/10.1038/nbt0807-849 Download citation * Issue

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