Reader TTS

Access through your institution Buy or subscribe Autophagy, a degradative pathway for removal of cytoplasmic proteins and organelles through sequestration in autophagosomes and lysosomal

degradation, has been suggested to be important for embryonic development. Rubinsztein and colleagues report in _Nature Communications_ (http://doi.org/jrd) that autophagy can be controlled

by the Hedgehog (HH) signalling pathway in mammalian cells and in _Drosophila melanogaster_. Activation of HH signalling by a variety of means impairs autophagy; specifically, autophagosome

formation. Known components of the HH signalling pathway — the receptors PTCH1 and PTCH2, the transmembrane protein SMO (which acts downstream of the receptors) and the transcription factor

GLI2 in mammalian cells — are also required for HH effects on autophagy. Regulation of autophagy by the HH pathway was also conserved in _Drosophila_. In an effort to identify downstream

targets of HH signalling that may directly modulate autophagy, the authors assessed changes in the expression patterns of an array of autophagy genes in response to HH signalling activation.

They found that PERK (also known as EIF2AK3) and GABARAP1, both implicated in autophagy, were reduced following HH activation; however, additional effectors were also likely to be

implicated in autophagy regulation by the HH pathway. The mechanistic details of how the HH pathway controls autophagy await future study. This is a preview of subscription content, access

via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy

this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: *

Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support Authors * Sowmya Swaminathan View author publications You can also search for this author inPubMed

 Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Swaminathan, S. Hedgehog signalling regulates autophagy. _Nat Cell Biol_ 14, 1250 (2012).

https://doi.org/10.1038/ncb2650 Download citation * Published: 30 November 2012 * Issue Date: December 2012 * DOI: https://doi.org/10.1038/ncb2650 SHARE THIS ARTICLE Anyone you share the

following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer

Nature SharedIt content-sharing initiative