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Access through your institution Buy or subscribe Khanna D _et al_. (2005) Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled

studies. _Arthritis Rheum_ 52: 3030–3038 A post-hoc analysis of two phase III, randomized, controlled studies has suggested that folic acid decreases the efficacy of methotrexate in

patients with rheumatoid arthritis (RA). Folic acid is used to reduce the side effects of methotrexate, but there has been controversy as to whether concomitant use of folic acid reduces the

efficacy of the drug. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues

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View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Murphy, R. Folic

acid reduces the efficacy of methotrexate. _Nat Rev Rheumatol_ 2, 4 (2006). https://doi.org/10.1038/ncprheum0052 Download citation * Issue Date: 01 January 2006 * DOI:

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