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Access through your institution Buy or subscribe SHAPING RESPONSES _Candida albicans_ can switch between yeast and filamentous morphologies. In the _EMBO Journal_, Underhill and colleagues

investigate whether the morphological differences between these two forms affect innate immune cell recognition. Dectin-1, a receptor for the fungal cell wall component β-glucan, recognizes

yeast but not filamentous forms of _C. albicans_. Most yeast β-glucan is shielded from dectin-1 recognition except for β-glucan exposed at scar sites formed during the budding process. _C.

albicans_ yeast, unlike filaments, can induce dectin-1-mediated macrophage phagocytosis and trigger reactive oxygen production. During filamentous growth, scar sites are not formed, making

β-glucan inaccessible to dectin-1 recognition and unable to induce dectin-1-mediated innate immune responses. Thus, the shape of _C. albicans_ affects how phagocytes recognize this fungus.

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permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Research Highlights. _Nat Immunol_ 6, 371 (2005). https://doi.org/10.1038/ni0405-371 Download citation * Issue Date: April 2005 * DOI:

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