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The 3020insC mutation in _Nod2_ is associated with Crohn's disease, but how it influences disease pathogenesis is unknown. A new study shows that the 3020insC mutant protein fails to

activate a key transcription factor that drives interleukin 10 expression, resulting in reduced production of this anti-inflammatory cytokine. Access through your institution Buy or

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J. Philpott is in the Department of Immunology and Stephen E. Girardin is in the Department of Laboratory Medicine and Pathobiology at the University of Toronto, Toronto, Ontario, Canada.

[email protected], Dana J Philpott & Stephen E Girardin Authors * Dana J Philpott View author publications You can also search for this author inPubMed Google Scholar * Stephen E

Girardin View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Philpott,

D., Girardin, S. Crohn's disease-associated Nod2 mutants reduce _IL10_ transcription. _Nat Immunol_ 10, 455–457 (2009). https://doi.org/10.1038/ni0509-455 Download citation * Issue

Date: May 2009 * DOI: https://doi.org/10.1038/ni0509-455 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

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