Immature disruption | Nature Reviews Cancer
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Access through your institution Buy or subscribe The heterozygous, neomorphic mutation of isocitrate dehydrogenase 1 (_IDH1_) in glioma results in the generation of D-2-hydroxyglutarate, a
proposed oncometabolite. A brain-specific (nestin–Cre) knock-in of one allele of _Idh1_ with an R132H mutation results in high levels of neuronal apoptosis, haemorrhage and perinatal
lethality. This is associated with the inhibition of collagen prolyl hydroxylases, which leads to the loss of collagen maturation and basement membrane disruption. A few GFAP-Cre mice
survive _Idh1_ R132H expression but do not develop glioma. This suggests that IDH1 mutation promotes glioma genesis only in the context of other mutations. This is a preview of subscription
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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Sasaki, M. et al. D-2-hydroxyglutarate produced by
mutant IDH1 perturbs collagen maturation and basement membrane function. _Genes Dev._ 27 Aug 2012 (doi:10.1101/gad.198200.112) Download references Authors * Nicola McCarthy View author
publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE McCarthy, N. Immature
disruption. _Nat Rev Cancer_ 12, 659 (2012). https://doi.org/10.1038/nrc3377 Download citation * Published: 24 September 2012 * Issue Date: October 2012 * DOI:
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