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Access through your institution Buy or subscribe Intrinsic resistance to chemotherapy in pancreatic ductal adenocarcinoma (PDA) has been attributed to stromal components, such as activated

pancreatic stellate cells (PSCs). Sherman _et al_. found that activation of the vitamin D receptor (VDR) can convert PSCs to a quiescent state. The VDR ligand calcipotriol induced

transcriptional reprogramming of PSCs and stromal remodelling. Furthermore, in a mouse model of PDA, treatment with calcipotriol plus gemcitabine increased delivery of gemcitabine to tumours

and significantly improved survival compared with gemcitabine alone. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution

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Contact customer support REFERENCES * Sherman, M. H. et al. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. _Cell_ 159,

80–93 (2014) Article  CAS  PubMed  PubMed Central  Google Scholar  Download references Authors * Sarah Seton-Rogers View author publications You can also search for this author inPubMed 

Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Seton-Rogers, S. Stromal modulation to prevent resistance. _Nat Rev Cancer_ 14, 707

(2014). https://doi.org/10.1038/nrc3855 Download citation * Published: 24 October 2014 * Issue Date: November 2014 * DOI: https://doi.org/10.1038/nrc3855 SHARE THIS ARTICLE Anyone you share

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