Nerves linked to prostate cancer

Nerves linked to prostate cancer


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Access through your institution Buy or subscribe A study in murine models of prostate cancer has confirmed several lines of preclinical evidence that pointed to a link between the nervous


system and tumour growth and metastasis. It was not previously known whether nerve fibres infiltrate tumours and alter their behaviour; now this connection has been established by Claire


Magnon, Paul Frenette and colleagues.“We published back in 2006 that signals from the sympathetic nervous system had played a role in the migration of haematopoietic stem cells, and


hypothesized that there might be some similarities between healthy and cancer stem cells,” says Frenette. The researchers established a xenograft mouse model of prostate cancer to monitor


the growth and dissemination of cancer. They observed that there were tumour-infiltrating sympathetic nerve fibres that had arisen from the normal prostate tissue, as well as intratumour


parasympathetic fibres. Furthermore, using chemical or surgical sympathectomy (destroying the nerves) they were able to prevent tumorigenesis. The importance of these nerves was confirmed


using a genetically modified mouse model with deficient adrenergic signalling, in which tumour development in the prostate was severely compromised. This is a preview of subscription


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ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Magnon, C. _ et al_. Autonomic nerve development contributes to


prostate cancer progression. _Science_ 10.1126/science.1236361 Download references Authors * Rebecca Kirk View author publications You can also search for this author inPubMed Google Scholar


RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kirk, R. Nerves linked to prostate cancer. _Nat Rev Clin Oncol_ 10, 487 (2013).


https://doi.org/10.1038/nrclinonc.2013.139 Download citation * Published: 30 July 2013 * Issue Date: September 2013 * DOI: https://doi.org/10.1038/nrclinonc.2013.139 SHARE THIS ARTICLE


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