A novel way of inhibiting a protein tyrosine phosphatase

A novel way of inhibiting a protein tyrosine phosphatase


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Access through your institution Buy or subscribe Protein tyrosine phosphatase 1B (PTP1B) is an established target for diabetes and obesity but identifying drug-like PTP1B inhibitors has


proved challenging. Haque _et al_. generated single-chain variable fragments of antibodies that stabilized the oxidized form of PTP1B and so inhibited its phosphatase function. Intracellular


expression of the antibodies enhanced insulin-induced tyrosyl phosphorylation of the β-subunit of the insulin receptor and its substrate, and increased insulin-induced phosphorylation of


AKT, suggesting that stabilization of the oxidized form of PTP1B could be a useful approach to design PTP inhibitors. This is a preview of subscription content, access via your institution


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about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Haque, A. et al. Conformation-sensing antibodies stabilize the oxidized form of PTP1B


and inhibit its phosphatase activity. _Cell_ 147, 185–198 (2011) Article  CAS  PubMed  PubMed Central  Google Scholar  Download references Authors * Charlotte Harrison View author


publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Harrison, C. A novel way of


inhibiting a protein tyrosine phosphatase. _Nat Rev Drug Discov_ 10, 902 (2011). https://doi.org/10.1038/nrd3618 Download citation * Published: 01 December 2011 * Issue Date: December 2011 *


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