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Access through your institution Buy or subscribe MEGABASE DELETIONS OF GENE DESERTS RESULT IN VIABLE MICE. Nóbrega, M. A. _et al_. _Nature_ 431, 988–992 (2004) In mammals, most of the genome

does not code for protein products, raising intriguing questions about its function. The debate intensified recently when ultraconserved noncoding regions were discovered in mammalian

genomes; however, without functional data, no answers were forthcoming. Nóbrega _et al_. report that large-scale deletions of so-called gene deserts, which include highly conserved noncoding

regions, have no adverse effects in mice that are homozygous for these deletions. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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our FAQs * Contact customer support RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE In Brief. _Nat Rev Genet_ 5, 883 (2004).

https://doi.org/10.1038/nrg1509 Download citation * Issue Date: December 2004 * DOI: https://doi.org/10.1038/nrg1509 SHARE THIS ARTICLE Anyone you share the following link with will be able

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