Functional antagonism and human brain evolution
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Access through your institution Buy or subscribe > human-specific duplication of _SRGAP2_ antagonizes the ancestral > gene function Both studies examined the SLIT–ROBO Rho
GTPase-activating protein 2 (_SRGAP2_) gene, which is involved in cortical development and has been highly conserved over mammalian evolution. Using fluorescent _in situ_ hybridization
(FISH) and high-coverage sequencing, Dennis and colleagues confirmed that _SRGAP2_ has been partially duplicated three times in the human lineage. The ancestral form of the gene, _SRGAP2A_,
was first duplicated approximately 3.4 million years ago (giving rise to _SRGAP2B_), and this was then followed by two later duplications (giving rise to _SRGAP2C_ and _SRGAP2D_)
approximately 2.4 million and 1 million years ago. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this
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support ORIGINAL RESEARCH PAPERS * Dennis, M. et al. Evolution of human-specific neural _SRGAP2_ genes by incomplete segmental duplication. _Cell_ 149, 912–922 (2012) Article CAS Google
Scholar * Charrier, C. et al. Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. _Cell_ 149, 923–935 (2012) Article CAS Google Scholar
Download references Authors * Bryony Jones View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS
ARTICLE CITE THIS ARTICLE Jones, B. Functional antagonism and human brain evolution. _Nat Rev Genet_ 13, 452 (2012). https://doi.org/10.1038/nrg3266 Download citation * Published: 07 June
2012 * Issue Date: July 2012 * DOI: https://doi.org/10.1038/nrg3266 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a
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