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Access through your institution Buy or subscribe In the white adipose tissue (WAT) of obese mice fed a high-fat diet (HFD) — and specifically in resident ATMs — there were increased levels

of _Xbp1_ mRNA splicing and increased expression of ER stress markers compared with mice fed a normal chow diet, which is in line with previous studies showing that excess nutrient handling

activates the IRE1α–XBP1 pathway. Mice with a myeloid-specific knockout of IRE1α (_Ern1_f/f;_Lyz2_-Cre mice; created by the authors) were resistant to HFD-induced obesity, having lower body

weight and adiposity, decreased hyperinsulinaemia and improved insulin sensitivity; this observation couples the ER stress response of macrophages to obesity-associated metabolic

dysfunction. > lack of IRE1α enhances energy expenditure and heat production > through adaptive thermogenesis This is a preview of subscription content, access via your institution

RELEVANT ARTICLES Open Access articles citing this article. * SUPPRESSION OF SENP3 ENHANCES MACROPHAGE ALTERNATIVE ACTIVATION BY MEDIATING IRF4 DE-SUMOYLATION IN ESCC PROGRESSION * Shaoyuan

Zhang * , Jianmin Gu *  … Lijie Tan _Cell Communication and Signaling_ Open Access 09 August 2024 ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio

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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Shan, B. et al. The metabolic ER stress

sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity. _Nat. Immunol._ http://dx.doi.org/10.1038/ni.3709 (2017) Download references Authors

* Kirsty Minton View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Minton, K. Stress-induced macrophage polarization. _Nat Rev Immunol_ 17, 277 (2017). https://doi.org/10.1038/nri.2017.41 Download citation * Published: 10 April 2017 * Issue Date: May 2017 *

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