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Access through your institution Buy or subscribe The NLRP6 inflammasome complex (which contains the adaptor protein ASC and caspase 1 in addition to NLRP6) is highly expressed in intestinal

epithelial cells and is required for the processing of interleukin-1β (IL-1β) and IL-18. Here, the authors observed that ASC-deficient mice developed more severe dextran sulphate sodium

(DSS)-induced colitis than wild-type mice. However, this was not the case for ASC-deficient mice that had been fostered by wild-type mothers. Moreover, fostering or co-housing of wild-type

mice with ASC-, caspase 1- or NLRP6-deficient mice (but not with mice deficient for other NLRP proteins) resulted in exacerbated DSS-induced colitis in wild-type animals, and this was

prevented by antibiotic treatment. Taken together, these findings suggest that defective NLRP6 inflammasome signalling results in gut colonization by a colitogenic microbiota, which is

transmissible and can displace the commensal microorganisms of wild-type mice. Indeed, mice with defective NLRP6 inflammasome signalling and wild-type mice co-housed with these knockout mice

shared a microbial profile that was distinct from that of single-housed wild-type animals. Further analysis showed that members of the Prevotellaceae family and the candidate division TM7

were the most prominent bacteria in the intestinal crypts of both the knockout and co-housed wild-type animals, but were absent from the intestine of control mice. This is a preview of

subscription content, access via your institution RELEVANT ARTICLES Open Access articles citing this article. * RELEVANCE AND CONSEQUENCE OF CHRONIC INFLAMMATION FOR OBESITY DEVELOPMENT *

Lisa Ruck * , Susanna Wiegand *  & Peter Kühnen _Molecular and Cellular Pediatrics_ Open Access 14 November 2023 ACCESS OPTIONS Access through your institution Subscribe to this journal

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ORIGINAL RESEARCH PAPER * Elinav, E. et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. _Cell_ 145, 745–757 (2011) Article  CAS  Google Scholar  Download

references Authors * Maria Papatriantafyllou View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Papatriantafyllou, M. Inflammasome shapes the microbiota. _Nat Rev Immunol_ 11, 439 (2011). https://doi.org/10.1038/nri3012 Download citation * Published: 17 June

2011 * Issue Date: July 2011 * DOI: https://doi.org/10.1038/nri3012 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a

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