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Access through your institution Buy or subscribe Proteolysis is a ubiquitous regulatory event that has a crucial role in many physiological and pathological processes. Two studies now

provide insights into the proteolytic cascade on a global scale. Dix _et al_. describe a robust and versatile proteomic platform (PROTOMAP) that enables the direct visualization of the

topography and magnitude of proteolytic events. By applying the approach to analyse the proteolytic events that are induced by the intrinsic apoptotic pathway in T cells, the authors

identified 91 characterized and 170 previously uncharacterized caspase substrates. Surprisingly, many of the cleaved proteins yield fragments that correspond to functional protein domains.

So, apoptotic proteolysis generates new, stable forms of proteins. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution

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Contact customer support ORIGINAL RESEARCH PAPERS * Dix, M. M. et al. Global mapping of the topography and magnitude of proteolytic events in apoptosis. _Cell_ 134, 679–691 (2008) Article 

CAS  Google Scholar  * Mahrus, S. et al. Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini. _Cell_ 22 Aug 2008 (doi:

10.1016/j.cell.2008.08.012) Article  CAS  Google Scholar  * Müller, F. J. et al. Regulatory networks define phenotypic classes of human stem cell lines. _Nature_ 24 Aug 2008 (doi:

10.1038/nature07213) Article  Google Scholar  Download references RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Technology Watch. _Nat Rev Mol Cell

Biol_ 9, 741 (2008). https://doi.org/10.1038/nrm2518 Download citation * Issue Date: October 2008 * DOI: https://doi.org/10.1038/nrm2518 SHARE THIS ARTICLE Anyone you share the following

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