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Access through your institution Buy or subscribe The 2012 Nobel Prize in Physiology or Medicine has been awarded to John Gurdon and Shinya Yamanaka “for the discovery that mature cells can

be reprogrammed to become pluripotent.” Gurdon's work dates back to the 1960s, when it was generally accepted that cell differentiation cannot be reversed. However, Gurdon found that

this was not the case; when he replaced the nucleus of an unfertilized frog egg with that from a differentiated intestinal cell, he saw that the egg could still give rise to tadpoles — a

technique now known as nuclear transfer. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal

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Authors * Rachel David View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS

ARTICLE David, R. A nobel endeavour. _Nat Rev Mol Cell Biol_ 13, 751 (2012). https://doi.org/10.1038/nrm3463 Download citation * Published: 17 October 2012 * Issue Date: December 2012 * DOI:

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