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Access through your institution Buy or subscribe The authors stressed male mouse pups by separating them from their mothers for 4 hours a day either between postnatal day 2 (P2) and P12

(early postnatal stress) or between P10 and P20 (late postnatal stress). In adulthood, these mice were subjected to chronic social defeat stress and subsequently tested for depression-like

behaviours — including anhedonia on the sucrose preference test, social avoidance behaviour, and immobility in the forced swim test. Following adult stress exposure, mice in the late (but

not the early) postnatal stress group were more likely to develop depression-like symptoms than were standard-reared controls. Thus, in mice, exposure to stress in the developmental window

between P10 and P20 sensitizes the brain to exposure to stress in adulthood. > both types of stress induce a 'depressive' transcriptional state in > the VTA This is a preview

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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Peña, C. J. et al. Early life stress confers lifelong stress susceptibility in mice

via ventral tegmental area OTX2. _Science_ 356, 1185–1188 (2017) Article  Google Scholar  Download references Authors * Natasha Bray View author publications You can also search for this

author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bray, N. A sensitive window. _Nat Rev Neurosci_ 18, 453 (2017).

https://doi.org/10.1038/nrn.2017.84 Download citation * Published: 06 July 2017 * Issue Date: August 2017 * DOI: https://doi.org/10.1038/nrn.2017.84 SHARE THIS ARTICLE Anyone you share the

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