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Access through your institution Buy or subscribe Pittsburgh compound B (PIB) could be used to quantify myelin loss in patients with multiple sclerosis (MS), according to a proof-of-concept

study published in _Annals of Neurology_. The quantification of demyelination in this disease could “improve our understanding of the pathophysiology of MS ... and provide a means of

evaluating new promyelinating strategies in future clinical trials”, says lead investigator Bruno Stankoff, of University Pierre et Marie Curie, Paris, France. Demyelination is one of the

main features of MS and MRI can detect demyelinating lesions; however, to date, no imaging technique is able to quantify demyelination or remyelination. Research has shown that derivatives

of the stain Congo Red bind to both mylein and amyloid plaques. This finding led Stankoff and colleagues to hypothesize that PIB, which is a thoflavin T derivative that binds to amyloid-β

and also displays an affinity for myelin, could be used as a myelin imaging marker. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your

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to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read

our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Stankoff, B. _ et al_. Imaging CNS myelin by PET in multiple sclerosis using the [11C]PIB. _Ann. Neurol._ doi:10.1002/ana.22320

Article  CAS  PubMed  Google Scholar  Download references Authors * Nick Jones View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS

Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jones, N. Can Pittsburgh compound B PET imaging quantify demyelination in MS?. _Nat Rev Neurol_ 7, 2 (2011).

https://doi.org/10.1038/nrneurol.2010.186 Download citation * Published: 10 January 2011 * Issue Date: January 2011 * DOI: https://doi.org/10.1038/nrneurol.2010.186 SHARE THIS ARTICLE Anyone

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