Could antibodies cause psychosis?
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Antibodies against neuronal cell surface receptors are more common among patients with psychosis, according to new research, suggesting that psychosis could be antibody-mediated. The finding
raises the possibility of treating some cases of psychosis with immunotherapy.
Psychosis is a common presenting symptom of autoantibody-mediated encephalitis, which most commonly involves antibodies against the N-methyl-D-aspartate (NMDA) receptor. This observation has
generated interest in whether the autoantibodies are responsible for the psychosis, and whether psychosis that is not associated with encephalitis could be mediated by the same antibodies.
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